糖尿病与牙周病关系的临床研究

目 的 探讨糖尿病与牙周病的相关性。方法 调查对比分析DM组与非糖尿病（NDM）组相关指标。再将DM组中的牙周病患者随机分为4组，并在控制血糖的基础上给予不同治疗。A组仅保持口腔清洁，不针对牙周病治疗;B组接受口腔常规治疗;C组接受口腔常规治疗联合甲硝唑控释药膜治疗;D组在C组基础上加用盐酸米诺环素。分析各组治疗效果。 结果 DM组牙周病发病率高于NDM组（P〈0.05）。牙周病病症指标与FPG呈正相关（r≥0.136, P〈0.05）。D组的治疗效果最佳，好转率和有效率分别为61.90%和73.81%，均高于其余3组（P〈0.05）。结论 糖尿病患者牙周病发病率高，控制血糖治疗并给予积极治疗可有助于降低牙周病发病率。

The clinical research on the relationship between the diabetes and the periodontal disease

Objective To explore the correlation between diabetes and periodontal disease. Methods In a retrospective survey, we analyzed the related indicators of the 450 Diabetics （DM group） and 450 non-diabetics （NDM group）. The patients with periodontal disease in DM group were randomly divided into four groups： A group A only keeping receiving oral hygiene without periodontal disease treatment, B group B receiving routine dental oral conventional treatment; group C receiving routine oral conventional treatment plus metronidazole, and group D receiving minocycline as add-on therapy to group C drugs ,and all four groups received hypoglycemic agents controlling high blood glucose. The therapeutic effect of 4 groups was analyzed. Results The prevalence of periodontal disease in the DM group was higher than the NDM group （P〈0.05）.There was significant positive correlation between the illness indicators of periodontal disease and fasting plasma glucose （FPG） （r≥0.136, P〈0.05）. The therapeutic effect of group D was the best, and the improvement rate indicators of periodontal disease and fasting plasma glucose were 61.90% and 73.81%, respectively, and the improvement rates were higher in group D than other three groups. Conclusion The diabetes has a significantly important influence on the periodontal disease. The glycemic control and physical activity treatment can help reduce the morbidity of periodontal disease.