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| 实验性颅脑损伤后脑组织NO的变化 | |
| 引用本文： | 李志强,袁先厚,袁忠惠. 实验性颅脑损伤后脑组织NO的变化[J]. 中国煤炭工业医学杂志, 2001, 4(1): 70-71 |
| 作者姓名： | 李志强 袁先厚 袁忠惠 |
| 作者单位： | 湖北医科大学附属第二医院神经外科 |
| 摘 要： | 目的 探讨脑损伤后急性期局部一氧化氮（NO）含量变化及其与脑水肿的关系。方法 采用自由落体法制造大鼠脑损伤后，于相应时间点取出脑组织测定其含水量、NO及Ca^2 浓度。结果 在损伤后急性期脑组织含水量、NO及Ca^2 含量均升高，其中Ca^2 浓度和NO含量分别于损伤后4h、8h达高峰，且Ca^2 升高趋势持续时间长。经检验，NO含量与脑组织含水量呈正相关。结论 NO在脑损伤急性期参与了脑水肿的发生过程。 |
| 关 键 词： | 颅脑损伤 脑水肿 一氧化氮 脑组织 大鼠 |
| 文章编号： | 1007-9564(2001)01-0070-02 |
| 修稿时间： | 2000-05-12 |
CHANGES OF NITRIC OXIDELEVEL IN BRAIN TISSUES AFTER EXPERIMENTAL FOCAL INJURY |
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| Li Zhiqiang,YUAN Xianhou,Yuan Zhonghui. CHANGES OF NITRIC OXIDELEVEL IN BRAIN TISSUES AFTER EXPERIMENTAL FOCAL INJURY[J]. Chinese Journal of Coal Industry Medicine, 2001, 4(1): 70-71 | |
| Authors: | Li Zhiqiang YUAN Xianhou Yuan Zhonghui |
| Affiliation: | Li Zhiqiang,Yuan Xianhou,Yuan Zhonghui,the Second Affiliated Hospital of Hubai Medical University,Wuhan 430071 |
| Abstract: | Objective To explore the changes of nitric oxide (NO) level and its relationship with brain edema in acutebrain injury.Methods After acute brain injury model was produced by free dropping of rats,brain tissues were obtained andits water concentration,Ca2 + and NO were measured.Results After brain injury,the water content,NO level and Ca2 + wereall increased.The peak levels of Ca2+ and NO emerged 4 hours and 8 hours after the injury respectively,and the increasing ofCa2 + tended to last for a longer time.Tests showed that No concentration was positively correlated with the water content inbrain tissues.Conclusion NO is involved in the occurrence of brain edema after acute brain injury. |
| Keywords: | Brain injury Brain edema Nitric oxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |