胰岛素样生长因子-1与老年缺血性脑血管病及其脂代谢的相关性研究

目的探讨老年缺血性脑血管病（ICVD）患者血清胰岛素样生长因子-1（IGF-1）和血清脂类水平的临床意义及相互关系。方法检测130例ICVD患者血清IGF-1和总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白胆固醇（LDL-C）和脂蛋白（a）LP（a）]的水平，并与43名健康老年人比较。结果脑动脉硬化、短暂性脑缺血发作（TIA）和脑梗死（CI）急性期患者血清IGF-1的含量均明显低于健康对照组（P〈0．05）。TIA伴有梗死灶者血清IGF-1的含量较无梗死灶者更低（P〈0．05）。脑血管病组总TC、TG、LDL-C和LP（a）水平均较健康老年组升高（P〈0．05）。老年缺血性脑血管病组IGF-1水平与TC、TG、LDL、LP（a）水平呈负相关（P〈0．01）。结论血清IGF1与老-年ICVD的发生发展及其脂代谢紊乱密切相关，并在脑梗死的缺血再灌注过程中发挥作用。

Correlation between serum insulin-like growth factor-1 and lipid metabolic disorder in aged patients with ischemic cerebrovascular diseases

ObjectiveTo investigate the changes of the serum level of insulin-like growth factor-1 (IGF-1) and lipid as well as their correlation in aged patients with ischemic cerebrovascular diseases(ICVD).MethodsSerum level of IGF-1, Lipoprotein(a) LP(a)], total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were detected in 130 cases of aged ICVD, as well as in 43 cases of healthy aged control.ResultsIGF-1 level in aged ICVD group was remarkably lower than that in control(P<0.05), and the levels of LP(a),TC, TG and LDL-C in aged ICVD group were significantly higher than that in control (P<0.05). The serum IGF-1 level in TIA patients with infarction was mower than those without infarction (P<0.05). In aged ICVD group, the serum IGF-1 level was negatively correlated with LP(a),TC, TG and LDL-C level (P<0.01). ConclusionIGF-1 decreased in the patients of aged ICVD, which shows a close relationship about the disorder of lipid metabolism, and may play a certain role in the course of occurrence and development of aged ICVD.