| 高效液相色谱法测定普伐他汀钠片的溶出度 |
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| 引用本文： | 龙汉金. 高效液相色谱法测定普伐他汀钠片的溶出度[J]. 中国现代药物应用, 2009, 3(20): 47-48 |
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| 作者姓名： | 龙汉金 |
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| 作者单位： | 湖南省醴陵市中医院药剂科,412200 |
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| 摘 要： | 目的建立高效液相色谱法测定普伐他汀钠片的溶出度试验方法。方法色谱柱为kromasil C18柱（4．6×250mm，5μm）；流动相为磷酸盐缓冲液（pH3．5）．甲醇（45：55）；检测波长：238nm。结果普伐他汀钠在0．03—0．36mg／ml范围内线性关系较好，r=0．9999，回收率为99．6％，RSD为1．27％。结论本方法简便、快速、准确、重复性好，可作为普伐他汀钠片的溶出度的检测方法。
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| 关 键 词： | 普伐他汀钠片 溶出度 高效液相色谱法 |
Determination of Dissolution of Pravastatin Sodium Tablets by HPLC |
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| LONG Han-jin. Determination of Dissolution of Pravastatin Sodium Tablets by HPLC[J]. Chinese Journal of Modern Drug Application, 2009, 3(20): 47-48 |
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| Authors: | LONG Han-jin |
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| Affiliation: | LONG Han-jin.( Department of Pharmacy, Liling Chinese Medicine Hospital, Liling 412200, China) |
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| Abstract: | Objective To establish HPLC method for detecting dissolution of Pravastatin Sodium tablets. Methods kromasil C18 colunm（4. 6 ×250 mm,5 μm） was used, the mobile phase was phosphate buffer solution（pH3.5）-methanol （45 ： 55 ）, the detection wavelength was 238 nm. Results The linear range of Pravastatin Sodium was 0. 03 - 0. 36 mg/ml, coefficient correlation r was 0. 9999, the average recovery of Pravastatin Sodium was 99. 6% with RSD 1.27%. Condusion The method is simple, rapid, accurate and repreatable. It can be used for detecting dissolution of Pravastatin Sodium tablets. |
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| Keywords: | Pravastatin Sodium tablets Dissolution HPLC |
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