Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches,Canada 2012/13–2016/17, the Canadian Vaccine Safety Network |
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| Institution: | 1. Vaccine Evaluation Center, BC Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada;2. School of Public and Population Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;3. Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Canada;4. Sinai Health System and University of Toronto, Toronto, Ontario, Canada;5. CHU de Québec-Université Laval, Québec, Canada;6. Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada;7. Department of Pediatrics, Dalhousie University and Canadian Center for Vaccinology, IWK Health Centre, Halifax, Nova Scotia, Canada;8. College of Pharmacy and Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada;9. Department of Pediatrics, University of Calgary and Alberta Health Services, Alberta Children’s Hospital Research Institute, Calgary, Canada;10. Department of Medicine, The Ottawa Hospital, University of Ottawa and the Ottawa Health Research Institute, Ottawa, Ontario, Canada |
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| Abstract: | BackgroundConcern about adverse events following immunization is frequently cited by both those who receive or decline vaccines. Neurological adverse events are especially concerning.ObjectivesOur aim was to detect associations between seasonal influenza vaccination and the occurrence of severe anesthesia/paresthesia or severe headaches.MethodsData were analyzed from the Canadian National Vaccine Safety network. Events occuring on days 0–7 were self-reported and prevented daily activity, led to school or work absenteeism, or required medical attention. Controls were the previous year’s vaccinees; events in controls were collected prior to the start of the influenza vaccination program of each year (2012/13 through 2016/17). Multivariable logistic regression was used to determine the association between seasonal influenza vaccination and the occurrence of anesthesia/paresthesia or severe headaches.ResultsThe total sample was 107,565 for investigating anesthesia/paresthesia and 97,420 for investigating severe headaches. Anesthesia/paresthesia was reported by 104/107,565 (0.10%) participants; 63/69,129 (0.09%) vaccinees and 41/38,436 (0.11%) controls (adjusted odds ratio (aOR) = 0.89; 95% CI = 0.60, 1.32). Severe headaches were reported by 1361/97,420 (1.40%) participants; 907/61,463 (1.48%) vaccinees and 454/35,957 (1.26%) controls (aOR = 1.21; 95% CI = 1.08, 1.36). No specific vaccine product was associated with severe headaches.ConclusionsOur study found no association between severe anesthesia/paresthesia and seasonal influenza vaccination. While there was an association with severe headaches as an adverse event following influenza vaccination, the rates of these events are similar to rates reported from clinical trials and are not a cause for additional concern. |
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| Keywords: | Neurological events Adverse event following immunization Vaccine safety Surveillance |
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