Durability of humoral immune responses to rubella following MMR vaccination |
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| Institution: | 1. Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA;2. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA;3. Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;1. Department of Epidemiology, School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China;2. Suzhou Center for Disease Control and Prevention, Suzhou, China;3. Suzhou University Affiliated Children’s Hospital, Suzhou, China;4. Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA;1. Department of Biology, University of Florida, United States;2. Emerging Pathogens Institute, University of Florida, United States;3. Department of Research, Epicentre, Paris, France;4. Departments of Nutrition and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, United States;1. Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France;2. German Cancer Research Center (DKFZ), Infections and Cancer Epidemiology, Im Neuenheimer Feld 280, Heidelberg, Germany;3. Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire de Montpellier, Unversity of Montpellier, France;4. Department of Biology & Pathology, Centre Hospitalier Universitaire de Montpellier, Montpellier, France;5. Center for Free Information, Screening and Diagnosis (CeGIDD), Centre Hospitalier Universitaire de Montpellier, Montpellier, France;6. Department of Medical Information (DIM), Centre Hospitalier Universitaire de Montpellier, Montpellier, France;7. Department of Infectious and Tropical Diseases, Centre Hospitalier Universitaire de Montpellier, Montpellier, France;1. Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97330, United States;2. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, United States;3. Department of Microbiology and Immunology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States;1. Sakai City Institute of Public Health, 3-2-8 Kaicho-Higashi, Sakai, Osaka, 590-0953, Japan;2. Department of Virology 3, National Institute of Infectious Diseases, 4-7-1 Musashimurayama, Tokyo, 208-0011, Japan;3. Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Sinjuku-ku, Tokyo, 162-8640, Japan |
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| Abstract: | BackgroundWhile administration of the measles-mumps-rubella (MMR-II®) vaccine has been effective at preventing rubella infection in the United States, the durability of humoral immunity to the rubella component of MMR vaccine has not been widely studied among older adolescents and adults.MethodsIn this longitudinal study, we sought to assess the durability of rubella virus (RV)-specific humoral immunity in a healthy population (n = 98) of adolescents and young adults at two timepoints: ~7 and ~17 years after two doses of MMR-II® vaccination. Levels of circulating antibodies specific to RV were measured by ELISA and an immune-colorimetric neutralization assay. RV-specific memory B cell responses were also measured by ELISpot.ResultsRubella-specific IgG antibody titers, neutralizing antibody titers, and memory B cell responses declined with increasing time since vaccination; however, these decreases were relatively moderate. Memory B cell responses exhibited a greater decline in men compared to women.ConclusionsCollectively, rubella-specific humoral immunity declines following vaccination, although subjects’ antibody titers remain well above the currently recognized threshold for protective immunity. Clinical correlates of protection based on neutralizing antibody titer and memory B cell ELISpot response should be defined. |
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| Keywords: | Rubella Antibodies MMR-II vaccine Rubella vaccine Humoral immunity Waning immunity |
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