Relationship between European Mitochondrial Haplogroups and Chronic Renal Allograft Rejection in Patients with Kidney Transplant |
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| Authors: | María Angeles JIMéNEZ-SOUSA Eduardo TAMAYO María GUZMáN-FULGENCIO Amanda FERNáNDEZ-RODRíGUEZ María HEREDIA-RODRIGUEZ Mónica GARCíA-áLVAREZ Jesús F BERMEJO-MARTIN Daniel PINEDA-TENOR Patricia RUIZ-GRANADO Elisa ALVAREZ-FUENTE Esther GóMEZ-SANCHEZ José I GóMEZ-HERRERAS Salvador RESINO |
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| Affiliation: | 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.;2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.;3. Unidad de Investigación Biomédica. Hospital Clínico Universitario-IECSCYL, Valladolid, Spain. |
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| Abstract: | Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom''s MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction. |
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| Keywords: | kidney transplant allograft rejection SNPs mitochondrial haplogroups mtDNA |
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