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A U-shaped association between serum betaine and incident risk of first ischemic stroke in hypertensive patients
Institution:1. State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China;2. Department of Pharmacy, Rational Medication Evaluation and Drug Delivery Technology Lab, Guangdong Key Laboratory of New Drug Screening, Nanfang Hospital, Southern Medical University, Guangzhou, PR China;3. Department of Neurology, First People''s Hospital, Lianyungang, PR China;4. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, PR China;5. Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, PR China;6. Department of Cardiology, Peking University First Hospital, Beijing, PR China;7. Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA;1. Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy;2. Section for Medical Statistics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria;3. Bundesministerium für Gesundheit und Frauen, Vienna, Austria;4. Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany;5. Department of Anaesthesiology, General Intensive Care and Pain Control, Division Cardiac-, Thoracic-, Vascular Anaesthesia and Intensive Care, Medical University Vienna, Vienna, Austria;1. Geisel School of Medicine at Dartmouth, Hanover, NH, United States;2. Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States;3. The Dartmouth Institute for Health Policy, Lebanon, NH, United States;4. Department of Kinesiology, University of New Hampshire, Durham, NH, United States;1. Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China;2. Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China;1. The Mombasa Hospital, P.O Box 84074-80100, Mombasa, Kenya;2. United States International University, P.O Box 46092-00100, Nairobi, Kenya;3. Department of Food, Nutrition and Dietetics, Kenyatta University, P.O Box 43844-00100, Nairobi, Kenya;1. Department of Kinesiology, University of Georgia, Athens, GA, USA;2. Department of Food, Nutrition, and Exercise Sciences, Florida State University, Tallahassee, FL, USA;3. Department of Exercise Science, Elon University, Elon, NC, USA;1. Department of Physical Therapy, Faculty of Health and Welfare, Tokushima Bunri University, Tokushima, Tokushima, Japan;2. Department of Rehabilitation, Kasei Tamura Hospital, Wakayama, Wakayama, Japan;3. Life and Medical Sciences Area, Health Sciences Discipline, Kobe University, Kobe, Hyogo, Japan
Abstract:
Keywords:Betaine  First stroke  First ischemic stroke  Hypertension  CSPPT"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"China Stroke Primary Prevention Trial  OR"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"odds ratio  CI"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"confidence intervals  TMAO"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"trimethylamine N-oxide  CVD"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"cardiovascular diseases  SBP"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"systolic blood pressure  DBP"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"diastolic blood pressure  eGFR"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"estimated glomerular filtration rate  BMI"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"body mass index  TC"}  {"#name":"keyword"  "$":{"id":"kwrd0125"}  "$$":[{"#name":"text"  "_":"total cholesterol  SD"}  {"#name":"keyword"  "$":{"id":"kwrd0135"}  "$$":[{"#name":"text"  "_":"standard deviation
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