The low carriage prevalence of pneumococcus among community-dwelling older people: A cross-sectional study in Japan |
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| Affiliation: | 1. Pediatric Research and Clinical Center for Infectious Diseases, Popov Str.9, Saint Petersburg, Russia, 197022 and North Western State Medical University named after I.I. Mechnikov, Kirochnaya Str. 41, St Petersburg, Russia, 191015;2. Rostropovich Vishnevskaya Foundation and Georgetown University Hospital Department of Pediatrics, 4200 Wisconsin Ave. # 200, Washington, DC, 20016, USA;3. I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8-2, Moscow, Russia, 119991;4. Smolensk State Medical University, Krupskoy Str. 28, Smolensk, Russia 214019;5. Pirogov Russian National Research Medical University, Ostrovityanova Str. 1, Moskva, Russia, 11799;6. Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str.9, Saint Petersburg, Russia, 197022;7. Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str.9, Saint Petersburg, Russia, 198022;8. Perm Clinical Center of the Federal Medical and Biological Agency, Tselinnaya Str., 27, Perm, Russia, 614056;9. E.A.Vagner Perm State Medical University, 26 Petropavlovskaya Str, Perm, Russia 614990;10. Yekaterinburg Research Institute of Viral Infections, Letnyaya Str 23, Yekaterinburg, Russia 620030;11. Regional Clinical Hospital, Kalinina Str. 40, Khanty-Mansiysk, Russia 628012;12. Khanty-Mansiysk State Medical Academy, Mira Str. 40. Khanty-Mansyisk, Russia 628011;13. Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Partizana Zheleznyaka Str. 1, Krasnoyarsk, Russia 660022;14. Far Eastern State Medical University, Karl Marx Str. 35, Khabarovsk, Russia 680000;15. Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, – Research Institute of Maternity and Childhood Protection, Voronezhskaya Str. 49, Khabarovsk, Russia 680022;p. Regional Pediatric Hospital, Baumana Str 22, Perm, Russia 614066;q. Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg, Russia, 194100;r. Krasnoyarsk State Medical University named after Professor V. F. Voino-Yasenetsky, Partizana Zheleznyaka Str. 1, Krasnoyarsk, Russia 660022;s. Perm City Pharmacy Academy, Pоlevaya Str. 2, Perm, Russia, 614990;t. E.A.Vagner Perm State Medical University, Petropavlovskaya Str. 26, Perm, Russia 614990 |
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| Abstract: | ![]()
BackgroundThe carriage prevalence of pneumococcus among community-dwelling older adults is not fully understood, especially in superaged societies. Our purpose was to elucidate the carriage prevalence of pneumococcus in the upper respiratory tract among Japanese community-dwelling adults aged ≥65 years.MethodsWe conducted a cross-sectional study of generally healthy community-dwelling adults aged ≥65 years in Nagasaki city, Japan. Demographic and clinical data and nasopharyngeal, oropharyngeal and saliva samples were collected from February 21st, 2018, to December 17th, 2018. The specimens were tested by culture and molecular methods.ResultsAmong a total of 504 enrolled participants, none were positive for pneumococcus by culture, and 22 were positive by PCR. The overall carriage prevalence was 4.4% (95% CI: 2.8–6.5%). The prevalence was highest in saliva samples, followed by oropharyngeal and nasopharyngeal samples. No demographic characteristics were associated with carriage prevalence, including age (4.7% among participants aged 65–74 years and 4.1% among those 75 years and older). Among the pneumococcal-positive participants, 18.2% were PCV13-covered serotypes.ConclusionsOur data suggest a low carriage prevalence of S. pneumoniae among community-dwelling older people in Japan. |
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| Keywords: | Pneumococcus Carriage prevalence Community-dwelling Older people Superaged society IPD" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" invasive pneumococcal disease pneumococcal autolysin gene quantitative PCR for pneumococcal autolysin gene NP" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" nasopharyngeal OP" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" oropharyngeal OR" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" odds ratio PCR" },{" #name" :" keyword" ," $" :{" id" :" k0100" }," $$" :[{" #name" :" text" ," _" :" polymerase chain reaction PCV13" },{" #name" :" keyword" ," $" :{" id" :" k0110" }," $$" :[{" #name" :" text" ," _" :" the 13-valent pneumococcal conjugate vaccine PPV23" },{" #name" :" keyword" ," $" :{" id" :" k0120" }," $$" :[{" #name" :" text" ," _" :" the 23-valent pneumococcal polysaccharide vaccine qPCR" },{" #name" :" keyword" ," $" :{" id" :" k0130" }," $$" :[{" #name" :" text" ," _" :" quantitative PCR STGG" },{" #name" :" keyword" ," $" :{" id" :" k0150" }," $$" :[{" #name" :" text" ," _" :" skim milk-tryptone-glucose-glycerol URT" },{" #name" :" keyword" ," $" :{" id" :" k0160" }," $$" :[{" #name" :" text" ," _" :" upper respiratory tract 95% CI" },{" #name" :" keyword" ," $" :{" id" :" k0170" }," $$" :[{" #name" :" text" ," _" :" 95% confidence interval |
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