人乳头瘤病毒感染与宫颈癌的研究进展

宫颈癌是女性常见的恶性肿瘤,仅次于乳腺癌,人乳头瘤病毒感染是其形成过程中的重要条件,但大多数感染人乳头瘤病毒的妇女可自行缓解,仅少数妇女持续感染并发展为宫颈上皮内瘤变、宫颈癌,说明宫颈癌的发生过程中还存在其他的协同因素.宫颈癌的治疗方法近年来无重大突破,因此,重点在于癌前病变的筛查及预防.目前人乳头瘤病毒疫苗的问世为宫颈癌的防治带来了希望,已经成为一个研究热点.该文就人乳头瘤病毒感染与宫颈癌的发生关系及人乳头瘤病毒疫苗的研究进展作了系统的回顾.

Progress in research on relationship between human papillomavirus infection and cervical carcinma

Cervical carcinoma,which its incidence rate is next to that of breast cancer,is one of the most common malignant tumors of the females.One of its important development conditions is HPV infection.Most HPV infected women can completely relief by herself,and only a minority of HPV infected women develop CIN or cervical carcinoma,suggesting that in addition to HPV infection there are other cofactors to induce development of cervical carcinoma.For recent years,there are no great breakthroughs in treatment of cervical carcinoma,so the research mainly focuses on screening and prevention of precancerous lesions of the disease.At present,emergence of HPV vaccine brings hopes for prevention and treatment of cervical carcinoma and it has become a hot-spot of the research.This paper reviewed progress in research on relationship between HPV infection and development of cervical carcinoma and development of HPV vaccine.