干细胞移植治疗脊髓损伤的实验研究进展

目的:探讨脊髓损伤后干细胞移植对神经功能恢复的作用机制及临床疗效.方法:检索国内外报道的实验大鼠脊髓损伤造模后干细胞移植的相关文献,对实验结果进行综合分析,评估大鼠神经功能恢复效果.结果:胚胎干细胞、神经干细胞、骨髓间充质干细胞、许旺细胞、嗅鞘细胞移植到受损脊髓实验大鼠后可分化成不同功能类型的神经细胞,能释放促进宿主神经元再生的营养因子,重建轴突的连续性.结论:脊髓损伤后干细胞移植可重建脊髓神经传导的连续性,预示着干细胞在脊髓损伤的治疗中具有良好的应用前景.

Research Progress on Stem Cell Transplantation for the Treatment of Spinal Cord Injury

Objective： To explore stem cell transplantation on the mechanism of recovery of neurological function after spinal cord injury and its clinical efficacy. Methods：Related literatures at home and abroad about experimental spinal cord injury in the literature for modeling stem cell transplantation were searched, a compre- hensive analysis of score data on the experimental results to assess the neurological recovery effect was conduc- ted. Results：Embryonic stem cells, neural stem cells, bone marrow mesenchymal stem cells, Schwann cells, olfactory ensheathing cells transplanted into spinal cord experimental rats can be divided into different functional nerve cells, release trophic factor to promote regeneration of host neurons, reconstruction axisconflict of continu- ity. Conclusions：Stem cell transplantation after spinal cord injury can rebuild the continuity of the spinal cord conduction . which indicates that the stem cells in the treatment of spinal cord iniury has a Rood prosoect.