左氧氟沙星三联方案补救根治幽门螺杆菌疗效

目的：研究左氧氟沙星三联方案补救根治幽门螺杆菌（Hp）的疗效和药物不良反应。方法：经传统三联根除脚治疗失败患者116例，随机分为A、B两组，A组60例，给予以左氧氟沙星为基础的三联补救治疗10d；B组56例给予常规四联补救治疗10d，观察两组疗效及不良反应。结果：A组54例完成治疗及随访，其中50例补救治疗成功，7例发生药物不良反应；B组51例完成治疗及随访，其中39例补救治疗成功，7例发生药物不良反应。A组的脚根除率明显高于B组（P〈0．05）。结论：以左氧氟沙星为主的三联方案补救根治印的疗效优于常规四联补救治疗，疗程短、不良反应少，值得临床推广。

Study of Levofloxacin Triple Scheme Remedial Therapy on Eradicated Treatment of Helicobacter Pylori

Objective ： To study the therapeutic effect and drug side-effects of levofloxacin triple scheme remedial therapy on eradi- cated treatment of helicobacter pylori （Hp）. Method： A total of 116 patients who were failed to be cured by routine triple therapy were randomly divided into two groups. Patients in group A（ n = 60 ）were treated by levofloxacin triple remedial therapy for 10 ds, while patients in group B（ n = 56） were treated by routine quadruple remedial therapy for 10 d. The therapeutic effect and drug side-effects of two groups were observed. Result： Fifty four patients in group A finished the treatment and visited fallow-up,in which 50 patients were cured successfully and 7 patients had slight side reactions. Fifty one patients in group B finished the treatment and visited follow-up, in which 39 patients were cured successfully and 7 patients had side reactions. The rate of Hp eradication in group A was higher than that of group B （ P 〈 0. 05 ）. Conclusion： The therapeutic effect of levofloxacin triple scheme remedial therapy on eradicate treatment of Hp is superior than that of the routine quadruple remedial therapy scheme. It has short period of treatment and less side-effects and is worthy to be recommended in clinic.