血清急性时相蛋白检测在消化系统恶性疾病诊断中的意义

目的:探讨急性时相蛋白检测在消化系统恶性疾病诊断的临床意义。方法:选取我院150例胃癌,结、直肠癌患者在术前行血清α1-酸性糖蛋白(α1-AG)、α1-抗胰蛋白酶(α1-AT)、C-反应蛋白(CRP)浓度检测,并与同期收治的消化系统良性疾病、应激患者及健康体检者进行对比观察。结果:消化系统良性疾病患者血清α1-AG、α1-AT、CRP水平比健康对照组略有增高,但差异无统计学意义(P>0.05);消化系统恶性疾病患者术前血清α1-AG、α1-AT、CRP水平较良性疾病组与健康对照组显著增高,差异有统计学意义(P<0.05)。结论:急性时相蛋白在消化系统恶性疾病中增高显著,表明急性时相蛋白的检测对胃肠良、恶性肿瘤的辅助诊断具有重要的临床意义。

Application of serum acute phase proteins detection in diagnosing of malignant digestive system disease

Objective: To discuss the application of serum acute phase proteins detection in diagnosing malignant digestive system disease.Methods: A total of 150 cases with gastric cancer and colorectal cancer from our hospital were enrolled and α1-AG,α1-AT and CRP concentration were detected before surgery.Patients with benign digestive system disease,stress response and healthy participants from the same period were observed for comparison.Results: Patients with benign digestive system disease had slightly higher levels of α1-AG,α-AT and CPR than healthy controls.However,the difference was not statistically significant(P>0.05).α1-AG,α1-AT and PCR levels in patients with malignant digestive system disease before surgery were significantly higher than that in benign disease group and healthy control group(P<0.05).Conclusions: Acute phase proteins increase significantly in malignant digestive system disease,indicating that acute phase protein detection has great clinical significance in the assist diagnosis of malignant and benign gastroenteric cancers.