阿托伐他汀对心衰微循环指标的影响

目的:探讨阿托伐他汀治疗慢性心力衰竭的疗效。方法:纳入2011年6月至2012年12月期间我院收治的慢性心力衰竭病例112例,对照组和观察组各56例。对照组采用基础治疗,观察组在此基础上口服阿托伐他汀40mg/d,连续服用8周。比较治疗前后两组患者氧化应激相关指标及微循环指标变化差异,同时对所有患者行超声心动图检查,比较治疗前后心功能变化。结果:治疗8周后,观察组患者超氧化物歧化酶(SOD)显著高于对照组(P<0.05),丙二醛(MDA)、过氧化脂质(LPO)、一氧化氮(NO)则显著低于对照组(P<0.05);治疗后观察组患者输入支管径、流速和输出支流速显著大于对照组(P<0.05);观察组微循环形态积分、流态积分、管周状态积分及总积分均显著低于对照组(P<0.05);除了左心室射血分数观察组患者略高于对照组,观察组左室收缩末内径、左室舒张末内径、心输出量等指标均显著优于对照组(P<0.05)。结论:在基础治疗的前提下,加载阿托伐他汀能有效改善慢性心力衰竭氧化应激状态及微循环,提高患者的心功能。

Influence of atorvastatin on microcirculation indexes of patients with chronic heart failure

Objective:To investigate the influence of atorvastatin on chronic heart failure(CHF).Methods:A total of 112 patients with CHF admitted to our hospital from June 2011 to December 2012 were selected and randomly divided into control group(56 cases) and observation group(56 cases)..Patients in control group were given basic treatment,while the observation group were also given oral atorvastatin,40 mg daily for 8 weeks on the basis of basic treatment.Then the indexes of oxidative stress,microcirculation and cardiac function before and after the treatment were analyzed and compared.Results:The SOD of observation group was higher than that of control group,MDA、LPO、NO were lower than those of control group;after treatment the nail fold microcirculation of the observation group was also significantly better than that of the control group(P<0.05);After treatment,the input vessel diameter,input flow velocity,and output flow velocity were all larger than that of the control group(P<0.05).The observation group showed significant lower microcirculation morphological scores,integral of the flow pattern and total scores were significantly lower than the control group(P<0.05);Except left ventricular ejection fraction,the observation group showed superior indexed including left ventricle end-systolic diameter,left ventricular end diastolic diameter,cardiac output etc.than the control group(P<0.05).Conclusion:Based on basic treatment,atorvastatin can improve the oxidative stress,microcirculation of patients with chronic heart failure.