Her-2蛋白在宫颈癌组织中的表达及其临床意义

目的:检测Her-2蛋白在宫颈癌组织中的表达,探讨其相关的临床意义。方法:收集手术治疗的宫颈癌患者手术切除标本60例,手术切除标本经病理诊断证实为宫颈癌,病例按照TNM分期分为Ⅰ(18例)、Ⅱ(29例)、Ⅲ(13例)三期,另取因子宫肌瘤而行子宫切除的正常宫颈上皮组织20例作为对照组;免疫组化检测宫颈组织中Her-2蛋白的表达。结果:Her-2蛋白在宫颈癌组织及正常组织中均有表达,其在宫颈癌组织中的阳性率为68.3%,显著高于正常对照宫颈组织的20%,差异有统计学意义(P<0.01)。Her-2蛋白在宫颈癌Ⅰ、Ⅱ、Ⅲ临床分期中阳性率分别为44.4%、75.7%、84.6%,不同临床分期之间的阳性率比较差异有统计学意义(P<0.05),随着临床分期的增加Her-2蛋白的表达率也相应的升高,差异有统计学意义(P<0.05)。结论:Her-2蛋白在宫颈癌的发生发展中起到一定的作用,可以用于肿瘤的分级以及预后判断等方面,同时其也有可能成为宫颈癌的一个潜在治疗靶点,具有显著的临床意义。

Expression of Her-2 protein in cervical cancer and its clinical significance

Objective: To detect the expression of Her-2 protein in cervical carcinoma,and explore the related clinical significance.Methods: A total of 60 cases with cervical cancer resection from 2008 January to 2010 January were collected,and were divided into three stages according to TNM stages: 18 cases at Ⅰstage,II 29 cases,Ⅲ13 cases.Normal cervical epithelial tissues in 20 cases were selected as control group.Expression of Her-2 protein was detected in cervical tissue by immunohistochemistry.Results: Her-2 protein was expressed in cervical carcinoma tissues and normal tissues,the positive rate in cervical cancer tissues was 68.3%,significantly higher than those in normal cervical tissue of 20%(P<0.01).Positive rates of Her-2 protein at Ⅰ,II,III clinical staging were 44.4%,75.7%,84.6%,there was significant difference in positive rate between different clinical stages(P<0.05),with the increase of clinical stage of Her-2 protein expression,the rate of the corresponding was increased(P<0.05).Conclusions: Her-2 protein plays a certain role in the development of cervical cancer,and can be used for tumor grading and prognosis.It may also be a potential therapeutic target in cervical cancer,with significant clinical value.