癌胚抗原联合甲胎蛋白检测在肝癌鉴别诊断中的应用价值

目的:分析癌胚抗原(CEA)联合甲胎蛋白(AFP)检测在肝癌鉴别诊断中的应用价值,为肝癌的临床防治提供参考。方法:对经临床病理学检查确诊的29例肝良性肿瘤(A组)、32例原发性肝癌(B组)、28例转移性肝癌患者(C组)分别采用电化学发光免疫分析法检测血清CEA及AFP水平。结果:C组CEA水平为(155.4±82.1)μg/L,均高于A组的(3.2±1.6)μg/L,B组的(36.4±9.3)μg/L(P<0.01);B组的AFP水平为(5319.8±2022.7)μg/L,均高于A组的(4.7±1.7)μg/L,C组的(75.8±22.6)μg/L(P<0.01);CEA对转移性肝癌检出率、敏感性、特异性分别为85.71%、89.47%、88.88%;AFP对原发性肝癌的检出率、敏感性、特异性分别为87.50%、86.97%、100.00%。结论:CEA联合AFP检测可提高肝癌诊断的敏感性及特异性,可为肝癌的鉴别诊断提供可靠依据。

Value of combined detection of carcinoembryonic antigen and alpha-fetoprotein in differential diagnosis of liver cancer

Objective:To analyze the value of combined detection of carcinoembryonic antigen and alpha-fetoprotein in differential diagnosis of liver cancer.Methods:Serum CEA and AFP levels of 29 patients with benign liver diseases(group A),32 patients with primary hepatic carcinoma(group B) and 28 cases of metastatic hepatic carcinoma(group C) which were confirmed by clinical pathological examination.Results:CEA level of group C was(155.4 ± 82.1) μg/L,higher than(3.2 ± 1.6) μg/L of group A and(36.4 ± 9.3) of group B(P<0.01).AFP level of group B was(5319.8 ± 2022.7) μg/L,higher than(4.7 ± 1.7) μg/L of group A and(75.8 ± 22.6) μg/L of group C(P<0.01).Detecting rate,sensitivity and specificity of CEA for detecting liver cancer was 85.71%,89.47% and 88.88%,respectively,while the corresponding data for AFP was 87.50%,86.97%,100.00%.Conclusions:Combined detection of CEA and AFP can improve the diagnostic sensitivity and specificity of liver cancer providing a reliable evidence for the differential diagnosis of liver cancer.