VitE对严重烧伤病人早期中性粒细胞吞噬功能损伤的防治作用

观察应用抗氧化剂 VitE 对22例大面积深度烧伤病人早期中性粒细胞吞噬功能损伤的防治作用。结果严重烧伤复苏后,非治疗组全血中超氧化物歧化酶(SOD)含量下降,丙二醛(MDA)值上升、中性粒细胞功能异常均较健康人组和 VitE 治疗组显著:血浆过氧化脂质产物 MDA 升高与中性粒细胞(PMN)吞噬率,吞噬指数均呈显著负相关;而 VitE 治疗组与对照组比较可见,治疗组 SOD 下降,MDA上升,PMN 功能下降均见减轻。结果提示,在严重烧伤早期复苏补液治疗中,应用自由基清除剂和抗氧化剂可防治严重烧伤后早期 PMN 功能损伤程度,提高机体防御能力。有关适宜用药剂量尚待进一步探讨。

Protective effects of vitamin E on impaired neutrophil phagocytic function in patients with severe burn

The protective effects of vitamin E on impaired neutrophil phagocytic function were observed in 22 patients with severe burn.The results showed that lower- ing of SOD values,elevation of MDA values significantly elevated and impairment of neutrophil phagocytic function were all more marked in the patients who did not receive vitamin E than that of vitamin E treated groups and the healthy control.It was also found that there was a significant inverse correlation between MDA values of blood plas- ma and neutrophil phagocyte rate and phagocyte index in the patients without vitamin E treatment.The results suggested that in severely burned patients the use of free radical scavenger and antioxidant could protect the neutrophil function to certain extent.The optimal dosage of vitamin E will be further assessed.