晚发性抑郁症与血管紧张素转化酶基因多态性关系研究

目的探讨晚发性抑郁症(LOD)与血管紧张素转换酶(ACE)基因第16内含子中Alu重复序列的插入/缺失(In-sertion/Deletion,I/D)多态性的关系。方法入组183例60~85岁老年人,晚发性抑郁症组(93例,下称LOD组)和正常对照组(90例,下称对照组),用聚合酶链式反应(PCR)法进行ACE基因I/D多态性分型。结果LOD组和对照组间基因型频率及等位基因频率分布差异无显著(χ2=0.241,P=0.886;χ2=0.127,P=0.722),各基因型亚型患者在年龄、性别、发病次数、病程、HAMD评分、有无精神病性症状、有无自杀企图间差异无显著(P均>0.05)。结论ACE基因I/D多态性与晚发性抑郁症无显著相关性。

Relationship between late-onset depression (LOD) and ACE gene I/D polymorphism

Objective To study the relationship between late-onset depression(LOD) and the angiotensin converting enzyme(ACE) gene polymorphism of Intron 16 insertion/deletion(I/D).Methods 93 LOD patients(60-83years) and 90 normal control subjects(60～85 years) were enrolled in this study.The intron 16 I/D polymorphism of ACE gene was analysed by means of polymerase chain reaction(PCR).Results The frequencies of genotype and allele of ACE gene did not show significant difference between LOD group and normal control group(χ2=0.241,P=0.866;χ2=0.127,P=0.722).Concerning age,gender,HAMD,episodestimes,duration of illness,with/without history of psychosis,with/without suicidal attempt,no significant differences were observed among three ACE genotype in LOD patients group(average P>0.05).Conclusions ACE gene I/D polymorphism did not significantly associate with LOD.