Girdin蛋白在胆管癌组织中的表达及意义

目的 探讨Girdin蛋白在胆管癌与癌旁组织中蛋白表达水平的差异及其与胆管癌临床病理特征的关系.方法 采用免疫组织化学SABC法,检测Girdin蛋白在42对胆管癌与其癌旁组织切片中的表达情况,并结合临床病理资料进行统计分析.结果 胆管癌组织中Girdin蛋白表达阳性率（79％）高于癌旁组织（52％）（P＜0.05）.胆管癌组织中Girdin的蛋白表达与胆管癌的淋巴结转移及远处转移呈正相关（P＜0.05）,与患者年龄、性别、病理分级、浸润深度、临床分期等的相关性无统计学意义（P＞0.05）.结论 Girdin蛋白在胆管癌组织中高表达,可能参与了胆管癌的转移与进展,这为胆管癌的预后判断和基因治疗提供新的理论依据.

Clinical significance of expression of Girdin in cholangiocarcinoma

Objectives To examine the expression of Girdin in cholangiocarcinoma and to analyze its relationship with the biological behaviors of cholangiocarcinoma.Methods Tissue microarray technique and immunohistochemistry were used to examine Girdin expression in 42 cholangiocarcinoma tissue and tomor-adjacent tissue specimens.The correlation between Girdin expression and clinicopathological features of cholangiocarcinoma was then analyzed.Results The positive rate of Girdn expression was significantly higher in cholangiocarcinoma than in tumor-adjacent tissue （79％ vs 52％,P ＜ 0.05）.Girdin expression was positively correlated with lymph node metastasis and distant metastasis.（both P ＜ 0.05）,but showed no significant correlation with age,sex,pathological grade,depth of infiltration,tumor stage （all P ＞ 0.05）.Conclusion Up-regulation of Girdin expression in cholangiocarcinoma may contribute to tumor metastasis and development.The result provides a reference for further study of signal transduction pathways of cholangiocarcinoma and lymph node metastasis in cholangiocarcinoma.