| 蒽环类药物普通制剂及脂质体制剂的心脏毒性研究进展 |
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| 引用本文： | 高翠霞,王蕾,白彬,李晓晶,彭悦颖,张聪聪,胡子鉴,吕承,李海燕.蒽环类药物普通制剂及脂质体制剂的心脏毒性研究进展[J].临床肿瘤学杂志,2022,27(1):88-93. |
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| 作者姓名： | 高翠霞 王蕾 白彬 李晓晶 彭悦颖 张聪聪 胡子鉴 吕承 李海燕 |
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| 作者单位： | 200040 上海 石药集团中奇制药技术(石家庄)有限公司医学部;050035 石药集团中奇制药技术(石家庄)有限公司医学部;200040 石药集团中奇制药技术(石家庄)有限公司转化医学部;201204 上海联拓生物科技有限公司;100191 北京大学第三医院心血管内科 |
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| 摘 要： | 蒽环类药物属于抗肿瘤抗生素,为细胞周期靶向非特异性药物,具有广谱、强效的特点,临床上广泛用于实体肿瘤和恶性血液系统肿瘤的治疗.但是,因为容易引起心脏毒性事件而使其临床应用受到了一定程度的限制.经多年研究表明,与蒽环类药物普通制剂相比,脂质体制剂不但疗效相当,而且能减轻心脏毒性.本文就蒽环类药物普通制剂和脂质体制剂心脏毒...
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| 关 键 词： | 蒽环类药物 脂质体蒽环类药物 心脏毒性 |
Research progress of cardiotoxicity of conventional and liposomal anthracyclines |
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| GAO Cuixia,WANG Lei,BAI Bin,LI Xiaojing,PENG Yueying,ZHANG Congcong,HU Zijian,LV Cheng,LI Haiyan.Research progress of cardiotoxicity of conventional and liposomal anthracyclines[J].Chinese Clinical Oncology,2022,27(1):88-93. |
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| Authors: | GAO Cuixia WANG Lei BAI Bin LI Xiaojing PENG Yueying ZHANG Congcong HU Zijian LV Cheng LI Haiyan |
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| Institution: | (Department of Medicine, CSPC ZhongQi Pharmaceutical Technology (Shijiazhuang);Co., Ltd., Shanghai 200040, China) |
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| Abstract: | Anthracyclines,antitumor antibiotics,and cell cycle targeted nonspecific drugs with broad-spectrum and high anti-tumor activity,have been widely used in solid tumors and hematologic malignancies.Their clinical use,however,is sometimes limited by the development of cardiotoxicity.Liposomal anthracyclines can decrease cardiotoxicity without decreasing the efficacy.This paper overviews the epidemiology,mechanism,prevention and treatment of cardiotoxicity of anthracycline common preparations and liposomes,in order to provide guidance for their clinical application. |
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| Keywords: | Anthracyclines Liposomal anthracyclines Cardiotoxicity |
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