非小细胞肺癌CT征象与Ki67表达的相关性研究

目的 探讨非小细胞肺癌CT征象与Ki67表达的关系.方法 回归性分析行胸部CT扫描且经手术及病理确诊具有Ki67免疫组化结果的非小细胞肺癌230例.根据Ki67表达百分比分为两组,高表达组59例(Ki67>20％),低表达组171例(Ki67≤20％),应用卡方检验及计Mann-Whitney U检验对CT参数进行统计...

Correlation study between CT signs of non-small cell lung cancer and Ki67 expression

Objective To investigate the relationship between the CT signs of non-small cell lung cancer and the expression of Ki67.Methods Retrospective analysis was performed on 230 cases of non-small cell lung cancer who underwent chest CT scans and were diagnosed with Ki67 immunohistochemical results by surgery and pathology.These cases were divided into two groups according to Ki67 expression percentage,59 cases in the high expression group(Ki67>20%),and 171 cases in the low expression group(Ki67≤20%).Chi-square test and Mann-Whitney U test were used to analyze the CT features statistically.The single factor combined with multivariate logistic regression model was used to screen out the predictive factors and predicted probability values,and the multi-parameter model was compared with each single parameter to predict the efficacy of Ki67 expression through the ROC curve analysis.Results The single factor results found that boundary,composition,bronchial inflation sign,nodular/mass type,obstructive emphysema,pleural effusion,enlarged lymph nodes,multiple enlarged lymph nodes,CT_mean,CT_min,SD,long and short diameter were significantly different between the two groups(P<0.05).Logistic regression results showed that boundary,composition,bronchial inflation sign,obstructive emphysema,multiple enlarged lymph nodes,CT_min,SD,and short diameter were effective predictors of Ki67 expression in non-small cell lung cancer.ROC curve results showed that the area under the curve of the multi-parameter model was 0.913,the sensitivity was 88.1%,and the specificity was 83.0%.The results were better than single factor parameters.Conclusion CT-related parameters can be used to identify the expression level of Ki67 in non-small cell lung cancer.The reliable predictors are boundary,composition,bronchial inflation sign,obstructive emphysema,multiple enlarged lymph nodes,CT_min,SD,and short diameter.These CT signs can provide reference for evaluating the ability of cancer cell proliferation of non-small cell lung cancer.