Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/reperfusion injury |
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| Authors: | Yongjun Peng Hesheng Wang Jianhua Sun Li Chen Meijuan Xu Jihong Chu |
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| Affiliation: | Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China |
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| Abstract: | This study used electroacupuncture at Renzhong (DU26) and Baihui (DU20) in a rat model of cerebral ischemia/reperfusion injury. Neurological deficit scores, western blotting, and reverse transcription-PCR results demonstrated that electroacupuncture markedly reduced neurological deficits, decreased corpus striatum aquaporin-4 protein and mRNA expression, and relieved damage to the blood-brain barrier in a rat model of cerebral ischemia/reperfusion injury. These results suggest that electroacupuncture most likely protects the blood-brain barrier by regulating aquaporin-4 expression following cerebral ischemia/reperfusion injury. |
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| Keywords: | electroacupuncture cerebral ischemia/reperfusion blood-brain barrier aquaporin-4 brain edema rat Renzhong (DU26) Baihui (DU20) brain injury regeneration neural regeneration |
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