主动免疫治疗原因不明习惯性流产后外周血免疫球蛋白及T淋巴细胞亚群的变化

目的:探讨原因不明习惯性流产患者外周血免疫球蛋白和T淋巴细胞亚群在主动免疫治疗前后的变化。方法:对33例原因不明习惯性流产患者作主动免疫治疗,对比治疗前后外周血免疫球蛋白及T淋巴细胞亚群含量的变化。结果:①治疗后免疫球蛋白IgG、IgM水平较治疗前明显下降(P<0.001,P<0.05)。②主动免疫组治疗前后CD3+细胞含量无明显差异(P>0.05)。③主动免疫组治疗后CD4+细胞较治疗前有明显减少(P<0.001)。④CD8+细胞在主动免疫治疗后较治疗前有明显升高。⑤CD4+/CD8+比例在主动免疫治疗后较治疗前明显下降。结论:主动免疫治疗后,外周血免疫球蛋白及T淋巴细胞亚群有了明显变化,更利于妊娠发展。

Changes of immunoglobulin and subtypes of T lymphocytes in peripheral blood in women with unexplained recurrent spontaneous abortion after active immunotherapy

Objective:To explore the changes of immunoglobulin and subtypes of T lymphocytes in peripheral blood in women with unexplained recurrent spontaneous abortion before and after active immunotherapy.Methods:33 patients with unexplained recurrent spontaneous abortion were treated with active immunotherapy, the changes of immunoglobulin and subtypes of T lymphocytes in peripheral blood before and after active immunotherapy were compared.Results:The levels of IgG and IgM after active immunotherapy were significantly lower than those before active immunotherapy (P<0.001, P<0.05).There was no significant difference in CD3+cells content before and after active immunotherapy (P>0.05).The amount of CD4+ cells after active immunotherapy was significantly lower than that before active immunotherapy (P<0.001).The amount of CD8+cells after active immunotherapy was significantly higher than that before active immunotherapy.The ratio of CD4+/CD8+ after active immunotherapy was significantly lower than that before active immunotherapy.Conclusion:After active immunotherapy, the changes of immunoglobulin and subtypes of T lymphocytes are obvious, which may be beneficial to pregnancy.