静脉滴注氨溴索佐治毛细支气管炎临床观察

目的:探讨静脉滴注氨溴索佐治毛细支气管炎的疗效及安全性。方法:以2006年1～12月住院的126例毛细支气管炎患儿为对照组,2007年1～12月住院的124例毛细支气管炎患儿为治疗组,两组均给予常规抗感染、激素、解痉、止咳等治疗,必要时吸痰。重症患儿吸氧、给予血管活性药物;有心衰时给予西地兰、速尿对症处理,治疗组在上述基础上静脉滴注盐酸氨溴索,2mg·kg-1·次-1,2次/d,疗程5～7天。比较两组症状、体征消失的时间,住院时间并观察治疗组的不良反应。结果:治疗组在改善喘憋症状,消除肺部哮鸣音、痰鸣音,缩短住院时间,显效率等方面均优于对照组。结论:静脉滴注氨溴索佐治毛细支气管炎疗效满意,未发现明显的不良反应,值得临床推广使用。

Clinical observation on bronchiolitis treated with intravenous drip of ambroxol

Objective: To explore the therapeutic effect and safety of bronchiolitis treated with intravenous drip of ambroxol. Methods: 126 hospitalized cases with bronchiolitis from January to December 2006 were selected as control group,and 124 hosptalized cases with bronchiolitis from January to December 2007 were selected as treatment group,the cases in the two groups were treated with anti-infection,hormone,spasmolysis and relieving cough,aspiration of sputum if necessary,the severe cases were treated with oxygen uptake and vasoactive drugs; the cases with heart failure were treated with cedilanid and furosemide,based on the treatment mentioned above, the cases in treatment group were treated with intravenous drip of ambroxol for 5 ～ 7 days,2 mg·kg -1,twice a day. The disappearance times of symptoms and signs,hospitalization time of the two groups and adverse reactions of treatment group were compared. Results: The therapeutic effects of treatment group were superior to those of control group in terms of improving wheezes symptom,removing pulmonary wheeze and rale,shortening hospitalization time and obvious effective rate. Conclusion: The therapeutic effect of intravenous drip of ambroxol is satisfactory in treatment of bronchiolitis,no obvious adverse reactions are found and the method is worth popularizing.