多环芳烃遗传毒性研究进展

多环芳烃类化合物是广泛存在于各种环境介质中的一类有机污染物,并能通过呼吸、饮食、饮水、皮肤接触等多种途径进入人体,对人体健康和环境产生严重危害。关于多环芳烃的毒性研究已经涉及遗传毒性、肝脏毒性、生长发育毒性及致癌性等方面,该文综述了其遗传毒性的研究进展,主要包括DNA损伤、染色体损伤以及遗传易感性等。

Research Progress on Genotoxity of Polycyclic Aromatic Hydrocarbons

Polycyclic aromatic hydrocarbons(PAHs) is a class of organic pollutants widely distributed in various environmental medium, and human exposure can occur by many routes (inhalation, ingestion, and skin contact), regardless of the source. PAHs can seriously impact human health and environment due to their high toxicity, stability. Studies on the toxicity of PAHs have involved in many fields, such as genotoxieity, hepatotoxicity, developmental toxicity, carcinogenesis and so on. The development of studies on genotoxicity of PAHs was reviewed in this paper, including DNA damage, chromosome damage and genetic susceptibility.