| 心脑血管疾病患者胆固醇酯转运蛋白活性测定 |
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| 引用本文： | 楼正青,庄一义. 心脑血管疾病患者胆固醇酯转运蛋白活性测定[J]. 医学研究生学报, 2001, 14(1): 42-44 |
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| 作者姓名： | 楼正青 庄一义 |
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| 作者单位： | 南京军区南京总医院解放军医学检验中心 |
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| 基金项目： | 为军队“九五”科研基金题!(96D0 2 5 ) |
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| 摘 要： | 目的 :探讨胆固醇酯转运蛋白 (CETP)活性与心脑血管疾病的关系。 方法 :应用体外合成 1 4 C标记的高密度脂蛋白 (HDL )样颗粒 ,测定了 45例冠心病患者、2 6例脑卒中患者和 40例健康人 CETP活性。 结果 :冠心病患者、脑卒中患者 CETP活性分别为 (17.6± 5 .4) %、(15 .2± 3.8) % ,而健康人为 (12 .7± 2 .0 ) % ,两组患者与健康人比较均有显著差异 (P<0 .0 1)。 结论 :提示 CETP与动脉粥样硬化的发生、发展密切相关。
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| 关 键 词： | 胆固醇酯转运蛋白 高密度脂蛋白 心脑血管疾病 |
| 文章编号： | 1008-8199(2001)01-0042-02 |
| 修稿时间： | 2000-04-24 |
Determination of cholesteryl ester transfer protein activity in patients with cardiocerebrovascular diseases |
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| LOU Zheng-qing,ZHUANG Yi-yi. Determination of cholesteryl ester transfer protein activity in patients with cardiocerebrovascular diseases[J]. Bulletin of Medical Postgraduate, 2001, 14(1): 42-44 |
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| Authors: | LOU Zheng-qing ZHUANG Yi-yi |
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| Abstract: | Objectives:To evaluate the relationship between the activity of cholesteryl ester transfer protein(CETP) and cardiocerebrovascular diseases. Methods:The CETP activity of 45 cases of coronary heart disease(CHD) and 26 cases of stroke were measured using the synthetic substrate of 14 C-radiolabeled discoidal bilayer particles as the cholesteryl ester donor and LDL as receptor. Results:The CEPT activity(x±s) of CHD and stroke patients were(17.6±5.4)% and(15.2±3.8)%,while the healthy controls were(12.7±2.0)%.The CEPT activities in CHD and stroke patients were significantly higher than that in healthy controls(P<0.01). Conclusions: CETP is related to the occurrence and development of atherosclerosis. |
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| Keywords: | Cholesteryl ester transfer protein Activity Coronary heart disease Stroke |
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