儿童过敏性紫癜221例分析

目的探讨儿童过敏性紫癜（HSP）的临床特点。方法对1995年1月-2006年12月在我院住院的221例患儿的发病特点、临床表现、肾损害的临床和病理等方面进行分析。结果①有诱因者70例占31．9％，其中感染最多见。②可累及多种组织器官，本组除皮损外，关节受累134例占60．5％，肾脏受累73例占33．0％，消化道受累93例占42．0％。③紫癜性肾炎是影响预后的关键，对其应行包括病因、临床、病理及转归四个方面系统诊断。结论对紫癜性肾炎患儿广泛开展肾活检对治疗及预后的判断有重要的意义。

Analysis of Henoch-Schonlein Purpura in 221 Children

Objective To investigate the clinical characteristic of Henoch-Schonlein purpura（HSP） in children. Methods The pathogenetic characteristics, clinical manifestations, as well as the clinical and pathological features of renal damage of 221 children with HSP in hospital（from January 1995 to December 2006） were evaluated. Results ①70 cases（32% ） had the disease inducement and infection was the most common factor. ②HSP results in multi-organic impairment. In this study,besides skin lesion, 134 cases（60.5% in total） combined with joint damage,73 cases（33% in total） with renal damage,93 cases（42% in total） with digestive disease. ③HSP nephritis was the key factor which decided the prognosis of HSP. Systemic diagnosis of HSP should been made in clinical work, which including etiopathogenesis, clinical analysis, pathology, and prognosis. Conclusions Renal biopsy is very helpful in guiding therapy and estimating prognosis of HSP nephritis in children.