参乌胶囊治疗老年轻度认知损害临床对照研究

目的：研究参乌胶囊治疗老年轻度认知损害(MCI)的临床疗效。方法：采用随机平行双盲双模拟对照试验的研究方法,对符合轻度认知损害(MCI)脾肾两虚,痰浊血瘀证诊断标准的166位患者,按计划分组投药,治疗组83例(口服参乌胶囊),对照组83例(口服茴拉西坦胶囊),疗程为90 d。并在治疗前后分别采用简易精神状态检查表(MMSE)、临床记忆量表(CMS)(甲套、乙套交替使用)和全面衰退量表(GDS)对认知功能和记忆商进行评估。结果：中药参乌胶囊和茴拉西坦均可以明显改善轻度认知损害患者的各项认知功能和行为能力的积分(P<0.01)。对痴呆的总体疗效,两药物效果相近。两药对记忆认知的作用也近似。对行为能力的改善方面,中药参乌胶囊的疗效明显优于茴拉西坦(P<0.05)。结论：中药参乌胶囊对MCI有确切的疗效。

Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment

Objective: To evaluate the effectiveness of Shenwu gelatin capsule (compound Chinese ginseng and fleeceflower root etc) in the treatment on senile mild cognitive impairment. Method: 166 patients meeting criteria for mild cognitive impairment were selected from patients in Dongzhimen Hospital and were randomly assigned into a treatment group (n=83 cases), given 5 capsules of Shenwu gelatin capsule, and a positive control group (n=83 cases), given 2 capsules of aniracetam with 3 placebo capsules. All subjects took this medication 3 times a day for 3 months. double-blind and double-moulding control were used in this study. At a baseline and end (three months later), all subjects were assessed using a battery consisting of MMSE and clinical memory scale (CMS). Result: Both Shenwu gelatin capsule and aniracetam can remarkably increase the score of memory quotient (MQ), P<0.01. They have the similarly effectiveness, there are no statistical difference between the two groups in effectiveness of increasing memory scores. Conclusion: Shenwu gelatin capsule has certain effects on mild cognitive impairment.