参芪地黄汤对难治性肾病综合征患者肾功能的影响

目的:探讨参芪地黄汤对难治性肾病综合征患者肾功能的影响。方法:将150例患者随机分为观察组和对照组各75例。对照组给予对症处理及标准激素治疗;观察组在对照组基础上给予中药参芪地黄汤治疗,观察并记录2组患者治疗前后尿白蛋白量、内生肌酐清除率、尿素氮、血肌酐、血浆白蛋白等肾功能变化情况、中医证候积分情况及临床疗效和不良反应的发生情况。结果:尿白蛋白量、内生肌酐清除率、尿素氮、血肌酐、血浆白蛋白含量2组均较治疗前改善,差异有统计学意义(P0.05),观察组改善更明显(P0.05)。中医证候积分治疗后2组均降低(P0.05);观察组降低更明显(P0.05)。总有效率观察组为88.00%,对照组为65.30%,2组比较差异有统计学意义(P0.05)。不良反应发生率观察组为6.67%,对照组为20.00%,,2组比较差异有统计学意义(P0.05)。结论:参芪地黄汤治疗难治性肾病综合征,可改善患者肾功能,提高临床疗效,降低药物不良反应。

The Effects of ShenQi DiHuang Tangon Renal Function of the Patients with Refractory Nephrotic Syndrome

Objective: To explore the effects ofShenQiDiHuangTangon renal function of the patients with refractory nephrotic syndrome. Methods: All 150 patients were randomly allocated to the observation group and the control group, 75 cases each group. The control group accepted corresponding therapy and standard hormone; the observation group tookShenQiDiHuangTangon the foundation of the control group accepted. The changes of renal function including urinary albumin, endogenous creatinine clearance rate, usea nitrogen, serum creatinine, serum al-bumin and others, TCM symptome scales, clinical effects and the incidence of adverse reaction of both groups were observed and recorded. Results: The contents of urinary albumin, endogenous creatinine clearance rate, usea nitro-gen, serum creatinine and serum albumin in both groups improved after treating compared with before treating obvi-ously, and the difference had statistical meaning (P<0.05), the improvement of the observation group was more ob-vious (P<0.05). TCM symptom scales decreased significantly in both groups after treating (P<0.05); and the de-crease of the observation group was more significant (P<0.05). Total effective rate of the observation group was 88.00%, higher than 65.30% of the control group, and the difference indicated statistical meaning (P<0.05). The in-cidence of adverse reaction of the observation group was 6.67%, lower than 20.00% of the control group, and the difference presented statistical meaning (P<0.05). Conclusion:ShenQiDiHuangTangin treating of the patients with refractory nephrotic syndrome could improve renal function and clinical effects, decrease the incidence of drug ad-verse reaction.