| 烟酰胺磷酸核糖转移酶与妇产科疾病 |
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| 引用本文： | 李彩虹（综述）,叶红（审校）. 烟酰胺磷酸核糖转移酶与妇产科疾病[J]. 国外医学:妇产科学分册, 2010, 37(2): 97-100 |
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| 作者姓名： | 李彩虹（综述） 叶红（审校） |
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| 作者单位： | 宜昌市中心人民医院三峡大学第一临床医学院妇产科,湖北省宜昌市443002 |
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| 摘 要： | 烟酰胺磷酸核糖转移酶（Nampt）是一种结构高度保守的细胞因子,在最初克隆后近十年中Nampt并未引起关注。自2005年后,越来越多的研究发现,Nampt具有很多功能,其不仅是一种能模拟胰岛素作用的肽类激素,还是一种具有多种生物效应的脂肪因子。Nampt还具有酶的活性,参与细胞多种功能的调控,并与人类多种疾病和病理状态的发生有密切的关系,因而引起高度关注。就Nampt的特点及其与妇产科疾病的关系综述。
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| 关 键 词： | 烟酰胺磷酸核糖转移酶 肽类激素 脂肪因子 酶 |
Nicotinamide Phosphoribosyl Transferase and Gynaecology and Obstetrics |
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| Affiliation: | LI Cai-hong,YE Hong.Department of Gynecology and Obstetrics,the Fisrt Clinical Medical College of Three Gorges University,Yichang 443002,Hubei Province,China |
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| Abstract: | Nicotinamide phosphoribosyltransferase（Nampt） is a cytokine with highly conserved structure.It received little notice during the first ten years.However,since 2005,Nampt has garnered an increasing attention due to accumulating evidence indicating that Nampt is a pleiotropic protein like peptide hormone,adipocytokine and nicotinamide phosphoribosyltransferase.Nampt is not only involved in regulating of cell multiple functions,but also implicated in the pathogenesis of a number of human diseases and conditions.This review will cover the current progress of the associations among Nampt and gynecologic and obstetric diseases or conditions. |
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| Keywords: | Nicotinamide phosphoribosyltransferase Peptide hormone Adipocytokine Enzyme |
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