生物可降解活性材料修复兔桡骨缺损的实验研究

目的 探讨用可降解多孔块状聚己内酯（PCL）作为骨形态发生蛋白（BMP）的载体，修复骨缺损的可行性。方法 采用兔桡骨骨缺损模型，用上述具有生物活性复合材料修复骨缺损，同时对照单纯PCL及同种异体脱钙骨，经不同的时间的X线片、X线计量学、组织形态学及电镜观察，了解PCL／BMP复合物的成骨作用。结果 PCL／BMP组不同时间新骨形成的量均优于单纯PCL组，其骨缺损修复的方式和速度与同种异体脱钙骨较相似。电镜观察表明，PCL的降解过程与单纯PCL组相比较，PCL／BMP组的降解速度较快，更符合骨缺损愈合的需要。结论 PCL是BMP的良好载体，有修复骨缺损的临床应用可行性。

EXPERIMENTAL STUDY IN RABBIT ON REPAIR OF RADIAL BONE DEFECT BY BIOACTIVE DEGRADABLE POLYMER

Objective To investigate the availability of bone defect repair by degradable porous polycaprolactam (PCL) as the carrier of bone morphogenetic protein (BMP). Methods Three different kinds of bone substitutes, including decalcified bone matrix, PCL BMP compounds and simple PCL, were implanted into the radial bone defects in 36 rabbits, and in the other 12 rabbits the bone defects were left untreated as control. X ray examination, X ray morphometry, histological and electron microscopic observation were performed at different time after operation. Results The quantity of new bone formation in PCL BMP group was prior to that in simple PCL group. The pattern and speed of bone defect repair in PCL BMP group were similar to those in decalcified bone matrix. Electron microscopic observation showed that the PCL BMP group degraded faster than simple PCL group, which was more suitable for bone repair. Conclusion PCL is a good carrier of BMP with potential for clinical use.