Agenesis of corpus callosum: prenatal diagnosis and prognosis |
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| Authors: | Marie-Laure Moutard Virginie Kieffer Josué Feingold François Kieffer Fanny Lewin Catherine Adamsbaum Antoinette Gélot Jaume Campistol i Plana Patrick van Bogaert Monique André Gérard Ponsot |
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| Affiliation: | (1) Services de Neuropédiatrie, Obstétrique, Radiologie, Hôpital Saint Vincent de Paul, 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France;(2) Réanimation Néonatale, Institut de Puériculture, Paris, France;(3) Laboratoire de Neuropathologie, Hôpital Trousseau, Paris, France;(4) Neuropediatria, Hospital Sant Joan de Déu, Barcelona, Spain;(5) Departement de Neuropédiatrie, ULB, Hôpital Erasme, Brussels, Belgium;(6) Service de Néonatologie, Maternité Régionale, Nancy, France |
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| Abstract: | ![]()
Introduction Agenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.Methods Neuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.Results Febrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80–109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80–89) increased and slowness, attentional troubles, and instability appeared.Conclusion This study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school. |
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| Keywords: | Corpus callosum Agenesis Antenatal Outcome |
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