多奈哌齐联合认知康复训练治疗认知障碍

目的:探讨多奈哌齐联合认知康复训练治疗轻度认知障碍的临床疗效。方法:90例轻度认知障碍患者随机分为2组,联合治疗组口服多奈哌齐联合认知康复训练治疗,对照组仅口服多奈哌齐,跟踪观察6个月,治疗前后均进行简易精神状态检查表(MMSE)评分与临床记忆量表检查,并对结果进行统计分析。结果:治疗后联合治疗组的MMSE评分和临床记忆量表测定中指向记忆、联想学习、人像特点联系回忆及总分等方面评分明显优于对照组,差异有统计学意义(P<0.05)。结论:治疗后两组患者认知功能均有改善,多奈哌齐联合认知康复训练治疗明显优于单用口服多奈哌齐治疗。

Effects of Rehabilitation Training Combined with Donepezil on the Cognitive Impairment Patients

Objective ：To explore the clinical efficacy rehabilitation training combined with the donepezil on the cognitive impairment patients with mild cognitive disorders. Methods ：90 cases of mild cognitive impairment patients were randomly divided into two groups： combined therapy group and only donepezil group, therapy tracking observed for 6 months. The efficacy were assessed with mini-mental state to check the table （MMSE） and clinical memory scale before and after treatment, and the results were statistically analyzed. Results ： MMSE score , determination of point to memory , associative learning , portrait characteristic associate memories and total score of clinical memory scale of the combined treatment group were significantly better than the control group after treatment （R 〈 0.05 ） . Conclusion：The cognitive function in patients shows some improvements after treatment. The efficacy of rehabilitation practice combined with the donepezil is significantly better than only donepezil treatment .