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| 异体脱钙骨基质骨粒骨水泥骨形态发生蛋白复合材料成骨诱导活性 | |
| 引用本文： | 周勇,董玉霞,范清宇,文艳华. 异体脱钙骨基质骨粒骨水泥骨形态发生蛋白复合材料成骨诱导活性[J]. 中国组织工程研究与临床康复, 2003, 7(6): 1010-1011 |
| 作者姓名： | 周勇 董玉霞 范清宇 文艳华 |
| 作者单位： | DepartmentofOrthopaedics，TangduHospital，FourthMilitaryMedicalUniversity，DepartmentofOrthopaedics，TangduHospital，FourthMilitaryMedicalUniversity，DepartmentofOrthopaedics，TangduHospital，FourthMilitaryMedicalUniversity，DepartmentofOrthopaedics，TangduHospital，FourthMilitaryMedicalUniversity Xi'an710038，ShanxiProvince，China，Xi'an710038，ShanxiProvince，China，Xi'an710038，ShanxiProvince，China，Xi'an710038，ShanxiProvince，China |
| 摘 要： | INTRODUCTIONTherecombinanthumanbonemorphogeneticprotein-2(rhBMP-2)hadbeenexpressedbytheeukaryoticcellsineightycentury犤1犦.TherhBMP-2combinedwiththedecalcifiedbonematrix(DBM)par-ticleswasimpregnatedwithbonecementtoproducethecompoundbonedefectrepairmaterialandtheboneinductivecapacityofitwasinvestigatedinourstudy.MATERIALSANDMETHODSDBMparticlesandthecompoundmaterialpreparationThe100-400μmgrainyDBMparticlesweremadeaccordingtotheUrist'smethods犤2犦.30mgDBMparticlescombinedwith… |
Capacity of bone induction of compound material of decalcified bone matrix combined with rhBMP- 2 and impregnated with bone cement |
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| Zhou Yong,Dong Yuxia,Fan Qingyu,Wen Yanhua Zhou Yong,Dong Yuxia,Fan Qingyu,Wen Yanhua. Capacity of bone induction of compound material of decalcified bone matrix combined with rhBMP- 2 and impregnated with bone cement[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(6): 1010-1011 | |
| Authors: | Zhou Yong Dong Yuxia Fan Qingyu Wen Yanhua Zhou Yong Dong Yuxia Fan Qingyu Wen Yanhua |
| Affiliation: | Department of Orthopaedics,Tangdu Hospital, Fourth Military Medical University,Xi'an 710038,Shanxi Province,China |
| Abstract: | AIM:To analyze bone inductive capacity of the compound material of decalcified bone matrix combined with rhBMP 2 and impregnated with bone cement.METHODS:To assess the experimental study, histological and Masson's methods were used.RESULTS:The effects of compound material on the induction of bone formation were investigated in NIH mouse models.It was observed that in the with rhBMP 2 group, mesenchymal cells gathered in the implanted material at the 7th day postoperation,chondrogenesis were found at 14 to 21 days after implantation,new bone formation were observed at about 21 to 28 days after surgery and the DBM particles were absorbed by the new generated tissues gradually.CONCLUSIONS:The compound material of DBM combined with rhBMP 2 and impregnated with bone cement could induce the proliferation and migration of mesenchymal tissues that could be differentiated into cartilage and formed new bone finally.The new bone could absorb DBM particles gradually.The compound material had fair capacity of bone induction. |
| Keywords: | bone induction decalcified bone matrix recombined human BMP 2 bone cement |
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