A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity |
| |
| Affiliation: | 1. Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China;2. Xinjiang Key Laboratory of Cardiovascular Research, Urumqi, Xinjiang, China;3. Department of Anaesthesiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China;4. Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia;5. Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, Xinjiang, China;6. Department of Surgery, Central Clinical School, Monash University, Melbourne, Victoria, Australia;1. Department of Neurosurgery and Brain Tumor Research Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China;2. Department of Neurosurgery, Suzhou Kowloon Hospital of Shanghai Jiaotong University School of Medicine, 118 Wansheng Street, 215021, Suzhou, China;3. Laboratory of Molecular Neuro-oncology, Texas Children''s Cancer Center, Baylor College of Medicine, Houston, TX, USA |
| |
| Abstract: | ![]()
The dust mite Dermatophagoides pteronyssinus is a major cause of allergic disease in the Western world. Der p 1 is considered to be the most immunodominant allergen involved in the expression of IgE-mediated dust-mite hypersensitivity. Here, Farouk Shakib and colleagues suggest that it is the proteolytic effect of Der p 1 on CD23 and CD25 which makes it such a potent inducer of IgE synthesis. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
