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| 兔眼后囊膜混浊模型的建立 | |
| 引用本文： | 李云川,曹倩,李兰,查旭,张远平,戴红梅,梁毓琳.兔眼后囊膜混浊模型的建立[J].国际眼科杂志,2014,14(1):31-33. |
| 作者姓名： | 李云川 曹倩 李兰 查旭 张远平 戴红梅 梁毓琳 |
| 作者单位： | 中国云南省昆明市第一人民医院眼科;中国云南省昆明市第一人民医院眼科;中国云南省昆明市第一人民医院眼科;中国云南省昆明市,昆明医科大学第二附属医院眼科;中国云南省昆明市,昆明医科大学第二附属医院眼科;中国云南省昆明市第一人民医院眼科;中国云南省昆明市第一人民医院眼科 |
| 基金项目： | 昆明市重点社会科学项目(No.昆科技字08S090207号) |
| 摘 要： | 目的：总结兔眼后囊膜混浊模型建立过程中的成功经验及注意事项。 方法：选择新西兰白兔10只，每只兔选取右眼进行超声乳化晶状体摘除术，对手术中的乳化功率、时间等参数进行统计。术后共随访3mo，观察术后并发症和后囊膜混浊的形成情况，按Odrich后囊膜混浊分级系统对术眼后囊膜混浊情况进行分级。 结果：10只兔中有1只术中发生后囊膜破裂，1只于术后1wk死亡，其余8例术后1mo开始出现后囊膜混浊，术后2mo，后囊膜混浊的范围扩大并快速发展，术后3mo，形成致密纤维化层。术后3mo表现为致密的纤维化层和较厚的纤维化层，可见明显的后囊膜混浊。 结论：利用兔眼透明晶状体行超声乳化手术可作为研究后囊膜混浊的理想动物模型，但要注意手术操作，防止并发症发生。 |
| 关 键 词： | 动物模型 兔 后囊膜混浊 超声乳化术 |
| 收稿时间： | 2013/9/27 0:00:00 |
| 修稿时间： | 2013/12/9 0:00:00 |
Summary on production experiences of posterior capsule opacification model in rabbit eye |
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| Yun-Chuan Li,Qian Cao,Lan Li,Xu Zh,Yuan-Ping Zhang,Hong-Mei Dai and Yu-Lin Liang.Summary on production experiences of posterior capsule opacification model in rabbit eye[J].International Journal of Ophthalmology,2014,14(1):31-33. | |
| Authors: | Yun-Chuan Li Qian Cao Lan Li Xu Zh Yuan-Ping Zhang Hong-Mei Dai and Yu-Lin Liang |
| Institution: | Department of Ophthalmology, the First People's Hospital of Kunming, Kunming 650000, Yunnan Province, China;Department of Ophthalmology, the First People's Hospital of Kunming, Kunming 650000, Yunnan Province, China;Department of Ophthalmology, the First People's Hospital of Kunming, Kunming 650000, Yunnan Province, China;Department of Ophthalmology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China;Department of Ophthalmology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China;Department of Ophthalmology, the First People's Hospital of Kunming, Kunming 650000, Yunnan Province, China;Department of Ophthalmology, the First People's Hospital of Kunming, Kunming 650000, Yunnan Province, China |
| Abstract: | AIM: To summarize experience of posterior capsule opacification(PCO)model in rabbit eye. METHODS: Ten New Zealand white rabbits whose right eyes had ultrasonic emulsification operation were randomly selected. Emulsifying power, time and other parameters were collected. The follow-up time was 3 months. The complications and the formation of PCO were recorded and classified according to Odrich PCO classification system. RESULTS: One case of 10 rabbits occurred posterior capsular rupture, 1 case died 1 week after surgery. PCO occurred in the remaining 8 rabbits 1 month after operation and range enlarged 2 months later. Dense fibrosis layer and thick fibrosis layer occurred 3 months later. CONCLUSION: An ideal PCO animal model can be built in rabbit eye. We should pay attention to reduce the complications. |
| Keywords: | animal model rabbit posterior capsule opacification phacoemulsification |
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