| 中国独龙族人群中细胞色素P450 2C19基因多态性的研究 |
| |
| 引用本文： | 唐莉,彭林,张松,叶峻杰,焦云萍,董兆文. 中国独龙族人群中细胞色素P450 2C19基因多态性的研究[J]. 中国药理学通报, 2001, 17(5): 556-558 |
| |
| 作者姓名： | 唐莉 彭林 张松 叶峻杰 焦云萍 董兆文 |
| |
| 作者单位： | 云南省计划生育科学技术研究所 |
| |
| 基金项目： | 本课题获国家科技部计划生育专项基金资助,No 998672国家计划生育科学技术研究所,北京 100081 |
| |
| 摘 要： | 目的 研究细胞色素P4 5 0 2C19(CYP2C19)基因在中国云南地区特有少数民族人群中的基因型及突变频率。方法 采用聚合酶链式反应 (PCR)与限制性内切酶片段长度多态性 (RFLP)技术。结果 2 0 5例独龙族人群中的基因型 (其中有一个家系 ) ,84人为CYP2C19野生型纯合子 (wt/wt) ;98人为CYP2C19m1杂合子 (wt/m1) ;2 3人为CYP2C19m1突变纯合子 (m1/m1)。突变频率为 0 3 5 1。结论 与国内外相关报道比较 ,结果与文献报道相符。
|
| 关 键 词： | 细胞色素P4502C19 基因型 聚合酶链式反应 限制性内切酶片段长度多态性 |
| 文章编号： | 1001-1978(2001)05-0556-03 |
Cytochrome P450 2C19 gene polymorphism in Chinese Dulong populatoin |
| |
| TANG Li,PENG Lin,ZHANG Song ,YE Jun Jie,JIAO Yun Ping,DONG Zhao Wen. Cytochrome P450 2C19 gene polymorphism in Chinese Dulong populatoin[J]. Chinese Pharmacological Bulletin, 2001, 17(5): 556-558 |
| |
| Authors: | TANG Li PENG Lin ZHANG Song YE Jun Jie JIAO Yun Ping DONG Zhao Wen |
| |
| Affiliation: | TANG Li,PENG Lin,ZHANG Song 1,YE Jun Jie,JIAO Yun Ping,DONG Zhao Wen 1 |
| |
| Abstract: | AIM To study the polymorphism and the mutation frenquency of the cytochrome P450 2C19 gene in the unique minority Dulong population in Yunnan province in China. METHODS Polymerase chain reaction(PCR) and restricted fragment length poymorphism (RFLP) were used. RESULT The gneotypes of 205 Dulong subjects were studied, 85 were homozygous for wide type(wt/wt); 98 were heterzygous for the CYP2C19m1(wt/m1) and 23 were homozygous for CYP2C19 m1(m1/m1).CONCLUSION The result accorded with correlative report in national and international. |
| |
| Keywords: | cytochrome P450 2C19 genotype polymerase chain reaction restricted fragment length polymorphism(RFLP). |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
