| 司维拉姆对慢性肾衰大鼠钙磷代谢和胎球蛋白A的影响 |
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| 引用本文： | 陈洪滔,何永成,曾爱莲,栾韶东,陈海波,刘全英. 司维拉姆对慢性肾衰大鼠钙磷代谢和胎球蛋白A的影响[J]. 河北医学, 2011, 0(11): 1447-1449 |
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| 作者姓名： | 陈洪滔 何永成 曾爱莲 栾韶东 陈海波 刘全英 |
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| 作者单位： | 广东省深圳市第二人民医院,广东 深圳,518035 |
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| 摘 要： | 目的：观察盐酸司维拉姆对慢性肾衰竭大鼠钙磷代谢和胎球蛋白A水平的影响。方法：30只SD雄性大鼠分别行一步法5/6肾切除(n=20，手术组)或假手术(n=10，对照组)，30只大鼠术后2周开始给予高磷饮食6周。动物分3组：模型组(手术n=10)，治疗组(手术+司维拉姆，n=10)，对照组(假手术n=10)，司维拉姆组给予...
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| 关 键 词： | 慢性肾衰竭 大 鼠 盐酸司维拉姆 血磷 胎球蛋白A |
Effects of Sevelamer Hydrochloride on Calcium-Phosphorous Metabolism and Serum Fetuin-A Concentration in Rats with Chronic Renal Insufficiency |
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| CHEN Hongtao,HE Yongcheng,ZENG Ailian,et al. Effects of Sevelamer Hydrochloride on Calcium-Phosphorous Metabolism and Serum Fetuin-A Concentration in Rats with Chronic Renal Insufficiency[J]. Hebei Medicine, 2011, 0(11): 1447-1449 |
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| Authors: | CHEN Hongtao HE Yongcheng ZENG Ailian et al |
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| Affiliation: | CHEN Hongtao,HE Yongcheng,ZENG Ailian,et al (The Second People's Hospital of Shenzhen,Guangdong Shenzhen 518035,China) |
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| Abstract: | Objective: To investigate the effects of sevelamer hydrochloride on calcium-phosphorous metabolism and serum fetuin A concentration in chronic renal insufficiency rats. Method: 30 male SD rats either underwent 5/6 nephrectomy(n=20) or sham operation(n=10),and then divided into 3 groups: model group(5/6 nephrectomy,n=10),treatment group(5/6 nephrectomy with sevelamer treatment,n=10) and sham group(sham operation,n=10).All rats were fed with hyperphosphoruos diet 2 weeks after the operation.Serum creatinine,c... |
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| Keywords: | Chronic renal insufficiency Rat Sevelamer hydrochloride Serum phosphorous Serum fetuin-A |
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