| 蛋白激酶C和蛋白酪氨酸激酶活性对缺血再灌注心肌细胞凋亡影响的实验研究 |
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| 引用本文： | 刘兴德,陈运贞. 蛋白激酶C和蛋白酪氨酸激酶活性对缺血再灌注心肌细胞凋亡影响的实验研究[J]. 重庆医科大学学报, 2000, 25(1): 20-22 |
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| 作者姓名： | 刘兴德 陈运贞 |
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| 作者单位： | 重庆医科大学临床学院心内科 400016;重庆医科大学临床学院心内科 400016 |
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| 摘 要： | 为探讨缺血预适应（Ｉｓｃｈｅｍｉｃ Ｐｒｅｃｏｎｄｉｔｉｏｎｉｎｇ,ＩＰ）早期以及蛋白激酶Ｃ（Ｐｒｏｔｅｉｎ Ｋｉｎａｓｅ Ｃ,ＰＫＣ）及蛋白酷氨酸激酶（Ｐｅｏｔｅｉｎ Ｔｙｒｏｓｉｎｅ Ｋｉｎａｓｅ,ＰＴＫ）激动剂和抑制剂对缺血再灌注（Ｉ／Ｒ）心肌细胞凋亡的影响以及ＩＰ效能发挥通路中央ＰＫＣ和ＰＴＫ的关系。用ＴＵＮＥＬ法检测Ｉ／Ｒ心肌细胞凋亡。结果显示：１、ＩＰ早期能显著降低Ｉ／Ｒ心肌细胞凋亡（
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| 关 键 词： | 蛋白激酶C 酪氨酸激酶 缺血再灌注心肌细胞凋亡 |
| 文章编号： | 0253-3626(2000)01-0020-03 |
| 修稿时间： | 1999-02-25 |
Experimental study on effect of PKC and protein tyrosine kinase on cardiomyocyte apoptosis during ischemia / reperfusion in rat heart |
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| LIU Xing-de,et al. Experimental study on effect of PKC and protein tyrosine kinase on cardiomyocyte apoptosis during ischemia / reperfusion in rat heart[J]. Journal of Chongqing Medical University, 2000, 25(1): 20-22 |
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| Authors: | LIU Xing-de et al |
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| Abstract: | The purpose of this study was to use the TUNEL method for datecting I/R cardiomyocyte apoptosis to investigate the effect of ischemic preconditioning(IP),the activators of protein kinase C(PKC) and protein tyrosine kinase(PTK) on ischemia/reperfusion(I/R) cardiomyocyte apoptosis,and the relationship betWeen PKC and PTK for IPs anti-apoptosis effect in rat hearts.The results showed that:(1)IP could reduce MR cardiomyocyte apoptosis significantly (P<0.01);(2)PMA,the activator of PKC,and anisomycin,the activator of PTK,could also reduce I/R anisomycins anti-apoptosis during MR,and lavendustin A,the inhibitor of PTK,could block the effect of PMAs anti -apoptosis during I/R.These data suggest both PMA and anisomycin could mimic IPs anti-apoptosis effect during I/ R;PTK seems to be downstream of PKC for IPs anti-apoptosis effect during im injury in rat hearts. |
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| Keywords: | Protein kinase C Protein tyrosine kinase Ischemia/reperfusion cardiomyocyte apoptosis |
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