芎芍胶囊对猪冠状动脉球囊损伤后血管重塑的影响

目的：探讨芎芍胶囊对猪冠状动脉球囊损伤后血管重塑的影响。方法：球囊扩张损伤猪冠状动脉左前降支（LAD）中段中膜的方法建立再狭窄（RS）模型。采用计量组织学方法，结合病理形态学分析和冠状动脉造影结果，研究药物对后期管腔丧失及血管重塑的影响。结果：血管重塑可解释（59±20）％的后期管腔丧失，各药物组在减少后期管腔丧失与对照组比较差异均有显著性（P＜0．05，P＜0．01）。在减少由血管重塑造成的后期管腔丧失方面，芎芍小、大剂量组与对照组比较差异均有显著性（P＜0．05，P＜0．01）。结论：血管重塑对于猪冠状动脉球囊损伤后期的管腔狭窄具有重要作用，芎芍胶囊可明显抑制猪冠状动脉球 伤后的病理性血管重塑，从而减少术后管腔丧失，预防再狭窄的形成。

Effect of Xiongshao Capsule on Vascular Remodeling in Porcine Coronary Balloon Injury Model

OBJECTIVE: To study the effect of Xiongshao Capsule (XS) on vascular remodeling in porcine coronary balloon injury model. METHODS: Restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. The effect of drugs on late lumen loss and vascular remodeling was evaluated with quantitative histological method by combining results from histopathological analysis and coronary arteriography. RESULTS: Vascular remodeling explained (59 +/- 20)% of late lumen loss. All drugs significantly reduced late lumen loss 4 weeks after balloon injury (P < 0.05 or 0.01). Both low-dose and high-dose XS markedly reduced late lumen loss resulting from vascular remodeling, as compared with the control group (P < 0.05 and P < 0.01 respectively). CONCLUSION: Vascular remodeling played an important role in late lumen stenosis after balloon injury of coronary artery. XS could significantly inhibit pathological vascular remodeling after balloon injury, thus reduce late lumen loss and prevent restenosis.