大骨节病的早期老化改变及其发病学意义

Presenile Changes in Tissues of Kashin-Beck Disease and Its Patbogenetic Significance

The selenium level and activity of glutathione peroxidase in blood of children living in Kaschin -Beck disease(KBD)ecdemic areas were lower than that in non-endemic areas, KBD children were deficient in selenium, their lipid compone- nts, structure and function of the red cell membrane and cartilage tissue were abnormal. That is, the phospholipid(PL) content in the tissues of the patient was less than that of the controls in endemic and non-endemic areas, Especially as the phosphatidylcholine(PC) content decreased significantly, but sphingomy- elin(SM)increased, the molar ratio of SM/PC and cholesterol(Ch)/PL increased. Increase of acauthocyte content was seen under the electron microscope and the fragility of erythrocytes was also increased, It indicated that there were me- mbrane defects and membrane damage in KBD. At the same time, the sulfation extent of muc- opolysaccharides in cartilage of patients was lower,and the collagen content was higher than that of controls. The presenile changes in lipid composition structure and function of biomem- branes and cartilage metabolism of KBD are very significant in studies on the aetiological pathogenesis of KBD and other ageing diseases.