Inheritance of intrahepatic cholestasis of pregnancy in one kindred

Hirvioja M-L, Kivinen S. Inheritance of intrahepatic cholestasis of pregnancy in one kindred
Clin Genet 1993: 43: 315–317. © Munksgaard, 1993
We report three sisters with intrahepatic cholestasis of pregnancy (ICP) and the pedigree of the family, including six: generations. ICP was observed in five successive generations; most of the patients also had cholelithiasis. The uniform expression, the complete penetrance of the trait and the direct parent-to-child transmission support the Mendelian dominant mode of inheritance. Determination of HLA A, B and C haplotype was made in five ICP patients, without any findings of HLA type common to everyone. X-linked inheritance cannot be excluded in this study.