|
|||||
|
|
| 心肌缺血再灌注损伤与心肌细胞凋亡的研究进展 | |
| 引用本文： | 李凯,郑世营. 心肌缺血再灌注损伤与心肌细胞凋亡的研究进展[J]. 医学综述, 2008, 14(1): 6-8 |
| 作者姓名： | 李凯 郑世营 |
| 作者单位： | 南京胸科医院心外科,南京,210029 |
| 基金项目： | 中华人民共和国卫生部999科研基金招标课题 |
| 摘 要： | 心肌缺血再灌注损伤中存在着不同程度的心肌细胞凋亡的现象。如何减少心肌细胞凋亡已成为心肌保护的研究热点之一,随着研究的不断深入,其在心肌缺血再灌注损伤中应用具有广泛的前景。综述缺血再灌注损伤引起心肌细胞凋亡的证据、可能的相关机制、参与调节的相关基因分子和信号转导、以及初步阐述了目前减少心肌细胞凋亡的方法(缺血预适应和药物预适应)。 |
| 关 键 词： | 心肌缺血 再灌注损伤 细胞凋亡 缺血预适应 病因学 |
| 文章编号： | 1006-2084（2008）01-0006-03 |
| 收稿时间： | 2006-12-19 |
| 修稿时间： | 2007-11-20 |
Research Progress of Myocardial Reperfusion Injury and Myocardial Apoptosis |
|
| LI Kai,ZHENG Shi-ying. Research Progress of Myocardial Reperfusion Injury and Myocardial Apoptosis[J]. Medical Recapitulate, 2008, 14(1): 6-8 | |
| Authors: | LI Kai ZHENG Shi-ying |
| Affiliation: | LI Kai, ZHENG Shi-ying.(Department of Cardiac Surgery, Nanjing Chest Hospital, Nanjing 210029, China) |
| Abstract: | Apoptosis with different degree can be found in myocardial reperfusion injury.How to reduce myocardial apoptosis is one of the hot spots in myocardial preservation.With the deepening study,its application in myocardial ischemia-reperfusion injury will have wide prospective.This article not only reviews cell apoptosis resulting from myocardial reperfusion injury about its evidence,related possible mechanism and related gene molecules and its signal transduction taking part in regulation,but also initially debates the methods to reduce the myocardial apoptosis at present(ischemic preconditioning and drug preconditioning). |
| Keywords: | Myocardial ischemia Reperfusion injury Apoptosis Ischemic preconditioning Etiology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |