| 三七皂甙对心肌腺苷三磷酸酶的影响(英文) |
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| 引用本文： | 陈吉球,张月光,李胜联,曾青,容明智.三七皂甙对心肌腺苷三磷酸酶的影响(英文)[J].中国药理学报(英文版),1994(4). |
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| 作者姓名： | 陈吉球 张月光 李胜联 曾青 容明智 |
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| 作者单位： | 桂林医学院病理生理教研室，桂林医学院病理生理教研室，桂林医学院病理生理教研室，桂林医学院病理生理教研室，桂林医学院病理生理教研室 桂林 541001 中国，桂林 541001 中国，桂林 541001 中国，桂林 541001 中国，桂林 541001 中国 |
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| 基金项目： | Medical Research Foundation of Department of Public Health of Guangxi,№ 9105. |
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| 摘 要： | 三七总皂甙(PNS)能抑制心肌总ATP酶活力,但对Na~( )-K~( )-ATP酶无明显影响。三七皂甙单体Rb_1及Rg_1对心肌总ATP酶活力均有抑制作用,但Rb_1的抑制效力显著大于Rg_1·Rb_1能抑制豚鼠离体心房肌的自律性和收缩性,Rg_1也能抑制豚鼠离体心房肌的自律性,但对心房肌的收缩性却无明显影响。提示PNS抑制心肌收缩力这一作用的主要有效成份是Rb_1·
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| 关 键 词： | 人参 皂甙类 钠-钾-交换腺苷三磷酸酶 腺苷三磷酸酶 心肌收缩 心房 |
Effects of Panax notoginseng saponins on myocardial adenosinetriphosphatase |
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| CHEN Ji-Qiu,ZHANG Yue-Guang,LI Sheng-Lian,ZENG Qing,RONG Ming-Zhi.Effects of Panax notoginseng saponins on myocardial adenosinetriphosphatase[J].Acta Pharmacologica Sinica,1994(4). |
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| Authors: | CHEN Ji-Qiu ZHANG Yue-Guang LI Sheng-Lian ZENG Qing RONG Ming-Zhi |
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| Abstract: | Effects of total Panax notogin-seng saponins (PNS) and Panax notoginseng saponin monomers Rb1 and Rg1(Rb1, Rg1) on total ATPase and Na( ) - K( ) - exchanging ATPase of guinea pig heart were studied. It was found that PNS inhibited the total my-ocardial ATPase, but had no significant effect on the myocardial Na( ) - K( ) - exchanging ATPase. The total ATPase was inhibited by Rg1, and more clearly by Rb1. The auto-maticity and contractility of isolated guinea pig atria were inhibited by Rb1. Rg1 decreased the spontaneous frequency of isolated guinea pig right atrium, but not markedly the contractility of the left atrium. These results demonstrate that Rb1 is the main ingredient in PNS. |
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| Keywords: | ginseng saponins Na( )- K[ ]-exchanging ATPase adenosinetriphos- phatase myocardial contraction heart atrium |
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