急性脑梗死患者血清超敏C反应蛋白的表达及意义

目的探讨急性脑梗死患者血清超敏C反应蛋白（hs—CRP）与患者临床特征的关系。方法用免疫透射比浊法测定82例急性脑梗死患者发病24h内的hs—CRP水平，同时选择年龄、性别相似的健康人40例为对照组。根据脑卒中患者临床神经功能缺损程度评分标准（NDS），对急性脑梗死患者进行评分，患者均进行CT／MRI扫描确诊。结果急性脑梗死组hs—CRP水平较对照组明显升高（P〈0．01），患者hs—CRP含量与其临床神经功能缺损程度评分及患者的年龄均呈正相关（均P〈0．05），而与患者的性别无相关性（P〉0．05）。结论急性脑梗死与hs—CRP水平关系密切，hs—CRP水平越高，则病情越重。hs—CRP可作为急性脑梗死的危险预测因子，也是一个判断病情严重程度的客观指标。

Expression and Clinical Significance of the Serum High-sensitivity C-reactive Protein in Acute Cerebral Infarction

Objective To investigate clinical significance of the the serum high-sensitivity C-reactive protein(hs-CRP)level in acute cerebral infarction patients.Methods 82 acute cerebral infarction patients and 40 healthy persons as control were enrolled in this study.The serum hs-CRP levels in 24 h after admission were determined with immunoturbidimetry.All the patients were finally diagnosed by CT and MRI and scored by clinic nerological function deficit scale(NDS).Results Compared with Control group,the serum hs-CRP level in acute cerebral infarction group increased significantly(P<0.01).The serum hs-CRP level was positively correlated with clinic nerological function deficit scale(NDS) and age of patients.(P<0.05),but no correlation with sex(P>0.05).Conclusion Relationship between the serum hs-CRP level and acute cerebral infarction is intimate.The higher the serum hs-CRP level,the more severe the pathogenetic,So the serum hs-CRP level is a risk factor for acute cerebral infarction and an objective indexe to evaluate the severity.