Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction |
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作者单位: | Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China |
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摘 要: | Background The clinical outcome of percutaneous coronary intervention (PCI) is poorer in women than that in men. This study aimed at comparing the impact of gender difference on the strategy of primary PCI in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods Two hundred and fifty-nine patients with STEMI who underwent primary PCI within 12 hours of symptom onset were enrolled. The male group consisted of 143 men aged 〉55 years, and a female group included 116 women without age limitation. Procedural success was defined as residual stenosis 〈20% with thrombolysis in myocardial infarction flow grade 〉2 and without death, emergency bypass surgery or disabling cerebral events during the hospitalization. The rate of major adverse cardiac events (MACE), including death, nonfatal myocardial infarction and target vessel revascularization during follow-up, was recorded. Results Female patients were more hypertensive and diabetic and with fewer cigarette smokers than male counterparts. The prevalence of angiographic 3-vessel disease was higher in the female group, but the procedural success rate was comparable between the two groups (94.4% vs 92.2%). The occurrence rate of MACE did not differ during the hospitalization (4.2% vs 6.0%, P=0.50), but was significantly higher in the female group during follow-up (mean (16.0±11.2) months) than that in the male group (5.4% vs 0.7%, P=0.02). Conclusion Despite a similar success rate of primary PCI and in-hospital outcomes in both genders, female patients with acute STEMI still have a worse prognosis during the long-term follow-up.
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关 键 词: | 性别 心肌梗死 经皮冠状干涉 治疗方法 |
Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction |
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Authors: | LIU Yu WANG Le-feng YANG Xin-chun GE Yong-gui WANG Hong-shi XU Li LI Wei-ming NI Zhu-hua XIA Kun CHI Yong-hui LI Qiang ZHANG Da-peng WU Xiao-qing SUN Hao GUO Zong-sheng |
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Institution: | LIU Yu(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);WANG Le-feng(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);YANG Xin-chun(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);GE Yong-gui(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);WANG Hong-shi(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);XU Li(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);LI Wei-ming(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);NI Zhu-hua(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);XIA Kun(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);CHI Yong-hui(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);LI Qiang(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);ZHANG Da-peng(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);WU Xiao-qing(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);SUN Hao(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China);GUO Zong-sheng(Heart Center,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China); |
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Abstract: | Background The clinical outcome of percutaneous coronary intervention (PCI) is poorer in women than that in men.This study aimed at comparing the impact of gender difference on the strategy of primary PCI in patients with acute ST-segment elevation myocardial infarction (STEMI).Methods Two hundred and fifty-nine patients with STEMI who underwent primary PCI within 12 hours of symptom onset were enrolled.The male group consisted of 143 men aged >55 years,and a female group included 116 women without age limitation.Procedural success was defined as residual stenosis <20% with thrombolysis in myocardial infarction flow grade>2 and without death,emergency bypass surgery or disabling cerebral events during the hospitalization.The rate of major adverse cardiac events (MACE),including death,nonfatal myocardial infarction and target vessel revascularization during follow-up,was recorded.Results Female patients were more hypertensive and diabetic and with fewer cigarette smokers than male counterparts.The prevalence of angiographic 3-vessel disease was higher in the female group,but the procedural success rate was comparable between the two groups (94.4% vs 92.2%).The occurrence rate of MACE did not differ during the hospitalization (4.2% vs 6.0%,P=0.50),but was significantly higher in the female group during follow-up (mean (16.0±11.2) months) than that in the male group (5.4% vs 0.7%,P=0.02).Conclusion Despite a similar success rate of primary PCI and in-hospital outcomes in both genders,female patients with acute STEMI still have a worse prognosis during the long-term follow-up. |
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Keywords: | gender myocardial infarction percutaneous coronary intervention outcomes |
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