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| 环氧化酶2在乳腺癌中的表达及其与淋巴管生成的关系 | |
| 引用本文： | 李爱琳,滕月娥,吴迪. 环氧化酶2在乳腺癌中的表达及其与淋巴管生成的关系[J]. 中国医科大学学报, 2007, 36(3): 312-313,327 |
| 作者姓名： | 李爱琳 滕月娥 吴迪 |
| 作者单位： | 1. 中国医科大学附属第一医院放疗科,辽宁,沈阳,110001 2. 中国医科大学附属第一医院肿瘤内科,辽宁,沈阳,110001 3. 第88期临床医学7年制 |
| 摘 要： | 目的:探讨环氧化酶2(COX-2)在乳腺癌组织中的表达及其与淋巴管生成的关系。方法:采用免疫组化S-P及SABC法检测87例乳腺癌组织COX-2和血管内皮生长因子受体3(VEGFR-3)表达,及20例癌旁组织COX-2的表达.计数肿瘤内淋巴管密度(LVD),并结合临床病理特征分析。结果:乳腺癌组织COX-2表达阳性率显著高于癌旁组织(P<0.05);淋巴结转移阳性组和阴性组的COX-2表达率有显著差异(P<0.01);淋巴管密度与COX-2表达呈正相关(P<0.01);且与淋巴结转移呈正相关(P<0.05)。结论:COX-2过表达可能参与肿瘤发生,并增强乳腺癌的淋巴浸润及转移潜能。 |
| 关 键 词： | 环氧合酶 淋巴管生成 淋巴管密度 乳腺癌 |
| 文章编号： | 0258-4646（2007）03-0312-02 |
| 修稿时间： | 2006-11-24 |
Expression of cyclooxygenase-2 and its relationship with lymphangiogenesis in breast cancer |
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| LI Ai-lin,TENG Yue-e,WU Di. Expression of cyclooxygenase-2 and its relationship with lymphangiogenesis in breast cancer[J]. Journal of China Medical University, 2007, 36(3): 312-313,327 | |
| Authors: | LI Ai-lin TENG Yue-e WU Di |
| Affiliation: | 1. Department of Radiotherapy, The First Affiliated Hospital, China Medical University, Shenyang 110001, China; 2. Department of Medical Oncology, The First Affiliated Hospital; 3.88K,7-year Program for Medicine, Faculty of Clinical Medicine |
| Abstract: | Objective:To investigate the expression of cyclooxygenase-2(COX-2)in breast cancer and its correlation with lymphangiogenesis.Methods:The expressions of COX-2 and vascular endothelial growth factor receptor-3(VEGFR-3)was determined by immunohistochemical S-P method and SABC method in 87 tumor tissues and 20 paratumor tissues from patients with breast cancer.The lymphatic vessels density(LVD)was counted,and its correlation with clinicopathological parameters was analyzed.Results:The positive expression rate of COX-2 in breast cancer tissues was significantly higher than that in paratumor tissues(P<0.05).There was significant difference in the positive expression rate of COX-2 between breast cancers with and without lymph node metastasis(P<0.05).LVD was positively correlated with the expression of both COX-2(P<0.01)and lymph node metastasis(P<0.05).Conclusion:COX-2 may be involved in the occurrence of breast cancer and promote the lymphovascular invasion and metastasis. |
| Keywords: | cyclooxygenase-2 lymphangiogenesis lymphatic vessels density breast cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |