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GnRHa在保守性手术后子宫内膜异位症患者中应用的系统评价
引用本文:吴淑芳,韦迪霞. GnRHa在保守性手术后子宫内膜异位症患者中应用的系统评价[J]. 海南医学, 2014, 0(8): 1127-1129
作者姓名:吴淑芳  韦迪霞
作者单位:吴淑芳 (三亚市人民医院妇产科,海南 三亚,572000); 韦迪霞 (三亚市人民医院妇产科,海南 三亚,572000);
摘    要:
目的探讨促性腺激素释放激素激动剂(CnRHa)在子宫内膜异位症患者保守性手术后应用的临床效果及安全性。方法将本院收治的60例子宫内膜异位症患者随机分为实验组和对照组,两组患者均给予保守性手术治疗,实验组患者在术后给予曲普瑞林治疗。比较两组患者临床治疗的有效率并观察用药期间不良反应的发生情况,随访3年后观察两组患者1年、2年、3年的累计妊娠率及复发率。结果实验组治疗的有效率及1年、2年、3年的累计妊娠率均显著高于对照组(P〈O.05);而实验组累积1年、2年、3年累积复发率显著低于对照组(P〈0.05)。实验组治疗期间可见潮热、阴道干、性欲减退等轻微不良反应,所有患者均可耐受。结论GnRHa应用于子宫内膜异位症患者保守性手术后,可以显著提高临床疗效,促进妊娠,降低复发率,且安全性较高,值得临床推广应用。

关 键 词:CmRHa  保守性手术  子宫内膜异位症

Evaluation on the application of GnRHa in patients with endometriosis after conservative surgery.
WU Shu-fang,WEI Di-xia. Evaluation on the application of GnRHa in patients with endometriosis after conservative surgery.[J]. Hainan Medical Journal, 2014, 0(8): 1127-1129
Authors:WU Shu-fang  WEI Di-xia
Affiliation:. (Department of Obstetrics and Gynecology, People's Hospital of Sanya City, Sanya 572000, Hainan, CHINA)
Abstract:
Objective To investigate the clinical effect and security ofgonadotropin-releasing hormone ago- nist (GnRHa) for patients with endometriosis after conservative surgery. Methods Sixty patients of uterine endome- triosis in our hospital were randomly divided into the experimental group and the control group. The two groups of pa- tients were treated with conservative surgery, while patients of the experimental group were given triptorelin treat- ment. The clinical efficacy of the two groups was compared and the occurrence of side reactions was observed during the treatment. The 1-year, 2-year, 3-year cumulative pregnancy rate and recurrence rate were observed in the 3-year follow-up. Results The clinical efficacy, the 1-year, 2-year, 3--year cumulative pregnancy rate of the experimental group were significantly higher than those of the control group (P〈0.05); 1-year, 2-year, 3-year cumulative recur- renee rate of the experimental group were significantly lower than those of the control group (P〈0.05). There were mild adverse reactions such as hot flashes, vaginal dryness, and loss of libido during treatment in the experimental group, which were tolerated by all patients. Conclusion GnRHa applied to patients with endometriosis after conser- vative surgery can significantly improve the clinical efficacy, promote pregnancy, reduce the relapse rate, and is of high security, which is worthy of clinical application.
Keywords:Gonadotropin-releasing hormone agonist (GnRHa)  Conservative surgery  Endometriosis
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