nm23-H1蛋白在大肠癌表达的研究

目的探索nm23-H1蛋白的表达水平与大肠癌发生、发展、组织学类型、转移的相关性.方法 76例大肠癌组织标本、43例癌旁组织标本及正常大肠黏膜标本通过免疫组织化学方法检测nm23-H1蛋白表达.结果大肠的正常黏膜有不同程度nm23-H1蛋白表达;大肠癌组织nm23-H1蛋白表达(80.3%)高于癌旁组织(58.1%,P＜0.05)及正常黏膜(48.8%,P＜0.001);nm23-H1蛋白表达未显示与大肠癌淋巴结转移或远处转移的相关性.结论大肠癌组织nm23-H1表达明显增高,提示nm23-H1蛋白的表达升高可能与大肠组织的恶变有关.

Expression of nm23-H1 Protein in Human Colorectal Carcinoma

Objective To explore the expression level of nm23 H1 protein and its relationship with occurrence, development, histopathologic type and metastasis of human colorectal carcinoma. Methods Samples including 76 carcinoma tissues, 43 para carcinoma tissues and normal colorectal mucosa from 76 cases with colorectal carcinoma were taken to be measured the expression level of nm23 H1 protein by immunohistochemistry. Results The expression level of nm23 H1 protein varied in normal colorectal mucosa, but it was significantly higher in colorectal carcinoma (80 3%) than in para carcinoma tissues (58 1%) or in normal colorectal mucosa (48 8%). No significant relation was found between the expression level of nm23 H1 protein and carcinoma metastasis. Conclusion The expression level of nm23 H1 protein in colorectal carcinoma obviously increases, which may play a significant role in the development of colorectal carcinoma.