| 新生儿大肠埃希菌化脓性脑膜炎临床特点及耐药性分析 |
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| 引用本文： | 孙增贤,兰菊红,张亚丽. 新生儿大肠埃希菌化脓性脑膜炎临床特点及耐药性分析[J]. 临床儿科杂志, 2016, 0(3): 172-175. DOI: 10.3969/j.issn.1000-3606.2016.03.003 |
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| 作者姓名： | 孙增贤 兰菊红 张亚丽 |
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| 作者单位： | 浙江丽水市中心医院 浙江丽水 323000 |
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| 摘 要： | 目的了解新生儿大肠埃希菌化脓性脑膜炎的临床特点及耐药性情况。方法回顾性分析2004年6月—2014年6月收治的46例新生儿大肠埃希菌化脓性脑膜炎的临床资料,46例新生儿分为社区感染组和院内感染组,以及2004年6月—2009年5月的早期组和2009年6月—2014年6月的晚期组,分别比较临床表现及产超广谱β内酰胺酶(ESBLs)检出率和药敏试验结果。结果患儿均以发热或体温不升,反应差,少吃或拒乳,呼吸、心率增快为临床表现。院内感染组ESBLs检出率明显高于社区感染组,晚期组ESBLs检出率明显高于早期组,差异均有统计学意义(P??0.05)。院内感染组对常用的头孢菌素类抗生素耐药性明显高于社区感染组,晚期组对常用的青霉素类、头孢菌素类抗生素耐药性明显高于早期组,差异均有统计学意义(P??0.05)。结论新生儿大肠埃希菌化脓性脑膜炎临床表现不典型,近年来大肠埃希菌对青霉素类及头孢菌素类抗生药物的耐药性显著上升,院内感染是获得ESBLs的高危因素。
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| 关 键 词： | 大肠埃希菌 化脓性脑膜炎 超广谱β内酰胺酶 新生儿 |
Analysis of clinical manifestations and drug resistance in purulent meningitis caused by Escherichia coli in ;neonates |
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| Abstract: | Objective To investigate the clinical features and drug resistance of neonatal purulent meningitis caused by Escherichia coli. Methods The clinical data of 46 neonates diagnosed with purulent meningitis caused by Escherichia coli were retrospectively analyzed from June 2004 to June 2014. The neonates were divided into community acquired infection group and nosocomial infection group, or early group (from June 2004 to May 2009) and late group (from 2009 June to June 2014). Result Fever, hypothermia, lethargy, poor feeding, tachypnea, and tachycardia were common clinical manifestations in all neonates. The detection rate of ESBLs was signiifcantly higher in nosocomial infection group than that in community acquired infection group (P?
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| Keywords: | Escherichia coli purulent meningitis extended spectrumβ-lactamases neonate |
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